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September 16-17, 2019 | Paris, France
Dementia and Alzheimer's Disease
13
th
World Congress on
Journal of Clinical Psychiatry and Cognitive Psychology | Volume: 03
Is Alzheimer a runaway Autoimmune disease?
Alain L Fymat
International Institute of Medicine and Science, USA
T
here are approximately 400 known neurological
diseases, some of which classified as mental disorders.
A number of these disorders are mediated by a disruption
or failure of the blood brain barrier. Unfortunately, the
convergence between the barrier studies and clinical
investigations has historically been limited. There is
evidence of inflammatory signaling at the brain barriers
that may be an important part of the body's response
to damage or infection. This signaling system appears
to change both with normal aging and during disease.
Changes may affect organic phenomena (or diapedesis)
of immune cells and active molecular transfer, or cause
rearrangement of the tight junctions and an increase
in passive permeability across barrier interfaces. While
palliative treatments are available, neurodegenerative
disorders in general, and Alzheimer in particular, have
generally been declared as incurable. The reason is that
we have not yet been able to identify the etiology and
deep biology of their root cause(s). I will posit that the
disruption of the blood brain barrier is part of the etiology
of the disease. I will further submit that the root cause
of the disease is the brain's autoimmune system having
gone rogue in its unsuccessful attempts to maintain brain
homeostasis between the antagonistic synaptoblastic and
synaptoclastic pressures. For a cure, I will lastly advocate
balancing these pressures by regulating the autoimmune
system rather than fiercely combating either the hyper-
excited synaptoblastic pressures or/and suppressing the
synaptoclasticonesbyemployingmoleculesthatcan induce
an immune response (antigens) or engineered immune
cells that can train the autoimmune system to tolerate the
process or tissue it is on track to damage. This idea has
the potential to cure a range of autoimmune disorders,
including especially neurological and neurodegenerative
disorders and especially Alzheimer. Caution must
nonetheless be exercised as deploying the immune system
to treat certain diseases can also potentially trigger other
autoimmune diseases, e.g., in the case of cancer, it may
additionally trigger rheumatoid arthritis and colitis.
e:
alain.fymat@fiimas.org