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allied
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Journal of Pharmacology and Therapeutic Research
Volume 1 Issue 1
Clinical Pharmacy 2017
Notes:
Page 38
December 07-09, 2017 | Rome, Italy
7
th
World Congress on
Clinical Pharmacy and Pharmacy Practice
Hydrogel-forming microneedle arrays:
Potential for use in minimally-invasive
lithium monitoring
Eyman Mohamed Eltayib
1,2
, Ryan F Donnelly
3
and
James C McElnay
3
1
Ahfad University for Women, Sudan
2
Alneelain University, Sudan
3
Queen’s University Belfast, United Kingdom
T
his work describes hydrogel-forming microneedle
(s) (MN) arrays for minimally-invasive extraction
and quantification of lithium
in vitro
and
in vivo
for the
first time. MN arrays, fabricated from aqueous blends
of hydrolyzed poly (methyl-vinyl ether-co-maleic
anhydride) and crosslinked by poly (ethyleneglycol),
imbibed interstitial fluid (ISF) upon skin insertion. Such
MN were always removed intact. In vitro, mean detected
lithium concentrations showed no significant difference
following 30 min MN application to excised neonatal
porcine skin for lithium citrate concentrations of 0.9 and
2 mmol/l. However, after 1 h application, the mean lithium
concentrations extracted were significantly different, being
appropriately concentration-dependent. In vivo, rats were
orally dosed with lithium citrate equivalent to 15 mg/kg and
30 mg/kg lithium carbonate, respectively. MN arrays were
applied 1 h after dosing and removed 1 h later. The two
groups, having received different doses, demonstrated
no significant difference between lithium concentrations
in serum or MN. However, the higher dosed rats
demonstrated a lithium concentration extracted from MN
arrays equivalent to a mean increase of 22.5% compared
to rats which received the lower dose. Hydrogel-forming
MN clearly have potential as a minimally-invasive tool for
lithium monitoring in outpatient settings. Future research
will focus on correlation between serum and MN lithium
concentrations.
Biography
Eyman Mohamed Eltayib is Assistant Professor of Pharmaceutics at School
of Pharmacy, Ahfad University for Women and Head of Pharmaceutics
Department Faculty of Pharmacy, Alneelain University. She has received
her Bachelor in Pharmacy from Faculty of Pharmacy, University of Khartoum
(2004) and Master’s degree in Clinical Pharmacology from Faculty of
Pharmacy, University of Medical Sciences and Technology (2008). Her PhD
in Pharmacy from School of Pharmacy, Queen’s University of Belfast (2016)
under the supervision of Professor Ryan F Donnelly.
eeltayib01@qub.ac.ukEyman Mohamed Eltayib et al., J Pharmacol Ther Res 2017