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Journal of Pharmacology and Therapeutic Research
Volume 1 Issue 1 Clinical Pharmacy 2017
Notes:
Page 37
December 07-09, 2017 | Rome, Italy
7th World Congress on
Clinical Pharmacy and Pharmacy Practice
Cisplatin-induced human peripheral blood
mononuclear cells oxidative stress and
nephrotoxicity in head and neck cancer
patients: The influence of hydrogen peroxide
Patricia Moriel, Júlia Coelho França Quintanilha, Marília Berlofa
Visacri, Vanessa Marcilio de Sousa, Larissa Brito Bastos, Camila
de Oliveira Vaz, João Paulo de Oliveira Guarnieri, Carina Malaguti,
Anibal Eugenio Vercesi and Carmen Passos Lima
University of Campinas, Brazil.
C isplatin is a widely used chemotherapeutic in the
treatment of head and neck cancer. However, its use
is restricted due to cisplatin’s nephrotoxicity caused by
oxidative stress. The aim of the study was to characterize
oxidative stress in peripheral blood mononuclear cells and
its effect in nephrotoxicity induced by cisplatin. It was a
prospective clinical and observational study at a hospital
in Brazil. Before and after five days of the chemotherapy
were collected blood of twenty-four patients to the
realization of the MitoSox Red, H2DCF-DA and Amplex
Red tests to determinate oxidative stress. Renal function
was expressed in serum creatinine, creatinine clearance,
and blood urea nitrogen (BUN). Serum creatinine and
creatinine clearance were classified by CTCAE. No test
showed significant variation after chemotherapy. Serum
creatinine varied from 0.8 ± 0.2 to 1.6 ± 1.1 mg/dL (p
<0.001); creatinine clerance from 100.0 ± 24.4 to 57.0
± 25.8 mL/min (p <0.001); BUN from 26.2 ± 7.8 to 61.7
± 28.4 (p <0.001). H2O2 production was correlated with
greater variations of serum creatinine (p = 0.004) and
were associated with higher grades of toxicity of serum
creatinine (p=0.004) and creatinine clearance (p<0.001).A
linear regression analyses showed a significant univariate
with a positive relation between H2O2 production and
serum creatinine (p = 0.013), creatinine clearance (p =
0.046), and BUN (p = 0.032); and a significant multivariate
positive relation between H2O2 production and BUN (p =
0.040). In conclusion, H2O2 was related with changes in
all the renal parameters.
Biography
Patricia Moriel is a full Professor in the Faculty of Pharmaceutical Science at
State University of Campinas (UNICAMP), Brazil. She is leader of the Clinical
Pharmacy Group that is involved in the study of pharmacotherapy, drug
adverse events, pharmacovigilance, pharmacokinetic e pharmacogenomics
influences in adverse events, especially in cancer. She has authored more
than 45 research articles, awards, conferences and the granting of a research
projects. She has been director of several works of Master in medical and
pharmaceutical science and doctoral theses
Patricia Moriel et al., J Pharmacol Ther Res 2017