clinical-pediatrics-2019-scientifictracks

6 / 11

allied
academies
Page 22
Notes:
June 12-13, 2019 | Edinburgh, Scotland
Pediatrics and Clinical Pediatrics
2nd World Congress on
Current Pediatric Research | Volume: 23
Treatment effect of probiotic Bacillus Clausii on Neonatal jaundice in late preterm
and term newborn babies: An experimental study
C Jayakumar, Thomas Panikasseril Varghese, Anjana Gopi, Manu Raj, Remya Sudevan and Haripriya Jayakumar
Amrita Institute of Medical Sciences, India
Objective: To evaluate the effect of prophylactic probiotic
Bacillus clausii treatment on the need and duration of
phototherapy in newborn babies. Design: Open labeled
clinical trial. Setting: Level II obstetric ward of a teaching
hospital in Southern India. Participants: A total of 1043
babies with a gestational age of more than 35 weeks
were enrolled in the study. There were 510 babies in
the probiotic Bacillus clausii intervention group and 533
babies in the control group. Intervention: Intervention
group babies < 37 weeks received 2 ml of Bacillus clausii
(2.5 ml for those >37 weeks) twice a day for 3 days. Main
outcome measure: The outcome measures were (i) Need
of phototherapy and (ii) Duration of phototherapy. Results:
A total of 32 babies in control group and 17 in intervention
group required phototherapy. This difference in need for
phototherapy was statistically significant between the
two groups (p 0.04). Treatment with probiotic reduced
the risk of need for phototherapy by 44% (RR 0.56, 95%
CI 0.32, 0.99).The median duration of phototherapy in
the intervention group was 18 hrs( IQR 16.50, 24.00) and
that of control group was 24 hrs (IQR 18.00, 48.00). This
difference in duration of phototherapy was statistically
significant (p=0.027). No adverse drug reactions were
noticed in the intervention group. What is already known:
The management of neonatal jaundice depends on
phototherapy and exchange transfusion. What this study
adds: Prophylactic probiotic therapy appears to reduce the
need and duration of phototherapy in neonatal jaundice.
Conclusion: Prophylactic treatment of probiotic Bacillus
clausii for three consecutive days reduced both the need as
well as the duration of phototherapy in new-born babies.
Speaker Biography
C Jayakumar currently serves as Head and Professor at the Department
of Paediatrics, School of Medicine, Kochi. He received his MBBS, DCH,
and MD from Govt. Medical College, Thiruvananthapuram. He has
served as the Head of Department at Govt. Medical College, Alleppey
from 2015 - 2016 and has held teaching posts (Associate Prof. to Prof.) in
Govt. Medical College of Kottayam, Alleppey, and Thiruvananthapuram
from 1989 through 2016. He was also awarded the Fellow of Indian
Academy of Paediatrics in 2011.
e:
C Jayakumar et al., Current Pediatric Research, Volume 23
ISSN: 0971-9032