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June 12-13, 2019 | Edinburgh, Scotland
Pediatrics and Clinical Pediatrics
2nd World Congress on
Current Pediatric Research | Volume: 23
Effect of bovine colostrum on the absolute neutrophil counts of Acute Lymphocytic
Leukemia patients undergoing Chemotherapy: A double-blind randomized placebo-
controlled study
Edith Cyrill L Caysido, Rainelda Runez and Ferdinand Ganggangan
Baguio General Hospital and Medical Center, Philippines
Background: Changes in the blood cell counts, such
as leukopenia and neutropenia, in patients with Acute
Lymphoblastic Leukemia (ALL) are common events
following chemotherapy. These commonly delay further
administration of chemotherapeutic agents. Furthermore,
the risk of infection rises correspondingly with the degree
of neutropenia. Bovine colostrum is a rich source of
immunoglobulins and other antimicrobial factors. These
immunoglobulins are believed to improve the immune
function and may be effective in the prevention of
neutropenia following chemotherapy.
Objective: To determine the efficacy of bovine colostrum
in preventing neutropenia among ALL patients undergoing
chemotherapy.
Methods : This study included pediatric patients, aged 6
months to 18 years old diagnosed with ALL undergoing
chemotherapy. Twenty-one subjects were randomly
assigned to receive bovine colostrum or placebo that were
taken twice a day for a week beginning from the first day
of chemotherapy. Baseline complete blood count (CBC)
and the absolute neutrophil count (ANC) were determined
before and after 7 days of giving the colostrum or placebo.
A t-test was applied to determine significant differences
before and after the supplementation on each group.
Results: Results showed that there was a significant
increase in ANC of patients given bovine colostrum as
compared to the placebo group with a p-value of 0.007.
There were also significant increases in the white blood
cells and platelet counts in those who were given bovine
colostrum, with p-values of <0.001 and 0.001, respectively.
No untoward effects were observed on both groups.
Conclusion: Bovine colostrum is effective in increasing the
ANC of ALL patients undergoing chemotherapy and with
no noted side effects.
Speaker Biography
Edith Cyrill L Caysido completed her residency in pediatrics at Bguio
General Hospital Medical Center Philippines last 2016. She is currently
a medical officer in a rural area practicing as a pediatrician in Mountain
Province Philipines.
e:
Edith Cyrill L Caysido et al., Current Pediatric Research, Volume 23
ISSN: 0971-9032