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June 12-13, 2019 | Edinburgh, Scotland
8th European Clinical Microbiology and Immunology Congress
&
3rd World congress on Biotechnology
Joint Event
Microbiology: Current Research | Volume: 3 | ISSN: 2591-8036
Novel intensified bioreactor by continuous product phase separating
Arjan Oudshoorn
Delft Advanced Biorenewables, The Netherlands
Innovations in molecular biology grow the number
of products that can be generated by biosynthesis
exponentially. Cost effective production is key in order
to successfully introduce those biosynthesized products
in novel market applications and/or replace, often fossil
based, chemicals. Cost effect production requires not only
strain improvement but requires all aspects of production
to be in-line with one-another. DAB has developed an in-
situ product removal (ISPR) methodology and integrated
this in a bioreactor for intensified microbial fermentations.
This intensified bioreactor allows continuous production
and ongoing product removal. The benefit of the ISPR
bioreactor, called the FAST (Fermentation Acceleration by
Separation Technology), is to increase the productivity (by
reducing product inhibition) and to lower the intensity of
the downstream processing steps. In this way operational
expenditure, especially direct downstream processing
cost, can be significantly reduced. This presentation gives
an overview of the most interesting results of a one-year
successful piloting campaign on multiphase fermentations
at the Bioprocess Pilot Facility in Delft. As an example, a
sesquiterpene producing E. coli extractive fermentation
is addressed. Organic phase separation capacity of the
intensified ‘FAST’ reactor can be tailored towards microbial
activity. Recovery efficiency can go >95% overall, while
fermentation is still ongoing. Based on the technical
performance of the reactor in the yearlong pilot campaign,
the readiness of the reactor concept is discussed; this,
in relation to its applicability in large scale microbial
production processes for advanced fuels and chemicals
as well as in relation to future cost-effective production
biosynthesis of chemicals.
Speaker Biography
Arjan Oudshoorn has a PhD from Delft University of Technology, The
Netherlands in separation technology; applied to in-situ product
removal of butanol fermentations. He is CTO of Delft Advanced Bio-
renewables (DAB). He has over 12 years of experience on fermentation
product separation and bioprocess development. He worked in three
start-up companies and led process development to three successful
pilots.
e:
Arjan Oudshoorn, Microbiol Curr Res, Volume 3
ISSN: 2591-8036