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Volume 2
J Chem Tech App 2018, Volume 2
ABUSE DRUGS BY GAS CHROMATOGRAPHY MASS SPECTRUM
Raafat Abdeldayem
Mansoura University, Egypt
Background:
Drugs of abuse are any drug or substance which if taken by any route (oral-snuffing-injection) will lead to mood
change, psychological disturbance and can affect brain functions and level of perception. The aim of this work is to evaluate the
usefulness of using urine immunoassay kits for detection of some drugs of abuse, and study the correlation between the results
obtained by EMIT and GC / MS techniques.
Materials & Methods:
Drug toxicology tests are most commonly performed on urine, since most drugs and their breakdown
products are excreted in the urine at higher concentration. A total number of 449 inhabitant urine samples were collected from
patients admitted to emergency hospital, Mansoura University. 449 urine samples were analyzed by EMIT and GC / MS for ben-
zodiazepine, barbiturate, opiate and cannabinoid. Results revealed that urine immunoassay kit is useful for rapid preliminary
screening of abuse drug. GC / MS results confirm that 245 samples (54.56 %) are positive of the total number of samples. These
positive samples by GC / MS were as follows; benzodiazepines; 159 ((clonazepam, oxazepam, temazepam), barbiturates; 58
(thiobarbiturate, butabarbital, seconal) and opiates; 28 (methadone metabolite)).
Conclusions & Recommendations:
GC / MS analysis must be done for accurate identification and confirmation of EMIT results.
In addition, it is recommended as the most suitable technique for obtaining optimum analytical results.