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Page 16
Journal of Biotechnology and Phytochemistry
Volume 1 Issue 3
Notes:
Chemistry World 2017
November 13-15, 2017 Athens, Greece
7th World Congress on
Chemistry
Wolfgang Tremel, J Biotech and Phyto 2017
Inorganic nanoparticles as enzyme mimics
Along-standing goal of biomimetic chemistry is the
design and synthesis of functional enzyme mimics.
The past three decades have seen a wide variety of
materials including metal complexes, polymers and
other biomolecules that mimic the structure and function
of naturally occurring enzymes. Among these, inorganic
nanoparticles bear a huge potential, because they are
more stable than their natural counterparts, while having
large surface areas and sizes comparable to those of
natural enzymes. Therefore, a considerable number of
“artificial enzymes” derived from inorganic nanomaterials
has been reported. We highlight recent progress in the
field of enzymatically active inorganic nanomaterials.
They are discussed based on nanoparticle properties
in solution, particle uptake in cells and clearance and
based on catalytic activities of nanoparticles compared
to those of the natural enzyme. The aim of this overview
is to determine - or even predict - which chemical type of
nanoparticles is of special interest for further research
in enzyme mimetics. Of all nanoparticles discussed,
vanadium oxide, molybdenum oxide, cerium oxide,
magnetite nanoparticles and molybdenum oxide films
showed catalytic activities and stabilities comparable
or superior to those of natural enzymes. Some medical
and biotechnological applications of enzyme mimics
and some prospects for further research are outlined.
Biography
Wolfgang Tremel studied chemistry and medicine at the universities in Bielefeld
and Münster. He received his PhD in chemistry from the University of Münster in
1984. After postdoctoral stays at the Hahn-Meitner Institute in Berlin, the DESY/
Hasylab in Hamburg, Cornell University and Iowa State University he moved to
Münster to complete his Habilitation. 1991 he joined the chemistry department in
Mainz as an associate professor and was promoted full professor for inorganic
chemistry in 1996. He has served several years as department chairman and as
chairman of the materials science center. He has been an editorial board member
of the Journal of Solid State Chemistry and Chemistry of Materials and an associate
editor of the Journal of Solid State Chemistry. He is currently an associated editor of
Dalton Transactions. He has π400 publications that have been cited π10000 times.
His current publication h-index is 53.
Wolfgang Tremel
Johannes Gutenberg University Mainz, Germany