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Journal of Biotechnology and Phytochemistry
Volume 1 Issue 3
Chemistry World 2017
Notes:
Page 25
November 13-15, 2017 Athens, Greece
7
th
World Congress on
Chemistry
Transition metal vinylidene mediated catalysis for use
in organic synthesis
Chulbom Lee
Seoul National University, South Korea
T
ransition metal vinylidene is organometallic complexes
derived from alkynes that are isomeric to more well-known
pi- and sigma-alkyne complexes. Our laboratory has been
engaged in the development of C–C bond-forming methods
that make use of alkynes via mechanisms involving a transition
metal vinylidene species as a catalytic intermediate. A wide
range of new reactions has been developed, which include enyne
cycloisomerizations, and various tandem processes effecting
hydrative, alkylative, and carboxylative cyclizations. Recently, in
a departure from these C-C bond forming cyclization processes,
our explorations have been focused on the oxygen-transfer to
the metal-bound unsaturated carbene. This approach has led
to the discovery of the alkyne oxygenative additions that occur
through the intermediacy of a metalloketene arising from
oxidation of the metal vinylidene. Discussed in this presentation
will be the design, implementation and mechanistic studies of
the oxygenative transition metal vinylidene-mediated catalytic
reactions.
Biography
Chulbom Lee has completed his PhD from Stanford University and Postdoctoral
studies from Memorial Sloan-Kettering Cancer Center. He is currently working
as a Professor of Chemistry at Seoul National University, while serving as Chair
of the International Affairs Committee of the Korean Chemical Society. He has
published more than 50 papers in the areas of natural product total synthesis
and transition metal medicated catalysis, and has been serving as an Editorial
Board Member of Chemical Reviews and Organic Chemistry Frontiers.
chulbom@snu.ac.krChulbom Lee, J Biotech and Phyto 2017