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April 15-16, 2019 | Milan, Italy
&
PUBLIC HEALTH,
EPIDEMIOLOGY AND NUTRITION
2nd World Congress on
CELL AND GENE THERAPY
2nd International Conference on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Joint Event on
Cell and Gene Therapy 2019 & Public Health Congress 2019 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 3
tic integrity in chloroquine-treated slice cultures, chloroquine being a well-known lysosomal disruptor used to model
age-related compromise of the autophagy- lysosomal pathway and producing the typical synaptic decline associated
with such stress. These results indicate that natural products can positively influence a protein clearance pathway in the
brain to promote synaptic maintenance. The findings suggest that CatB positive modulation leads to enhanced synap-
tic health, indicating a natural preventative strategy to attenuate early proteinopathy and reduce the risk of age-related
cognitive impairment.