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April 15-16, 2019 | Milan, Italy
&
PUBLIC HEALTH,
EPIDEMIOLOGY AND NUTRITION
2nd World Congress on
CELL AND GENE THERAPY
2nd International Conference on
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Joint Event on
Cell and Gene Therapy 2019 & Public Health Congress 2019 Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 3
MONOHYDRIC PHENOL IMPACT ON THE
STATE OF CEREBRAL BLOOD FLOW AND
COGNITIVE FUNCTIONS OF CHILDREN
Introduction: It is known that among the factors which induce the devel-
opment of cerebrovascular disorders are hypoxia and the impact of toxic
substances on the central nervous system, phenol and its derivatives (cresols)
belong to the group of highly hazardous substances (category 2). The main
sources of anthropogenic phenols are chemicals such as coke and petro-
chemicals, textiles, pulp and paper industry. Phenols and cresols are able to
accumulate in the brain parenchyma. This may lead to the development of
cerebrovascular disorders. The objective of this study is to evaluate the pat-
terns of cerebral haemodynamics and cognitive function impairments for
children with vegetovascular dystonia associated with exposure of monohy-
dric phenols.
Conclusions: Thus, dysfunction associated with aerogenic phenol and cresol
influence is characterized the linear velocity of the blood flow in the cerebral
arteries, a low level of audio-verbal memory, the overall mental development
and a high degree of anxiety are the effect markers of conditions of phenol
and cresol influence. Identified patterns of cognitive, behavioural status and
cerebral haemodynamics are recorded on the background of marker devia-
tions of homeostatic parameters concerning phenol in children in the form
of increased level of regulatory hormones and cholinergic neurotransmitters
(adrenocorticotropic hormone, cortisol, serotonin and cGMP), increased lipid
peroxidation products, activation and consequent depletion of antioxidant
blood activity and an increase of MDA concentration. Submitted patterns
of cerebral blood flow and cognitive and behavioural functions can be used
as an additional criterion of dysfunctions of the central humoral- metabolic
mechanisms in children with influence of monohydric phenols.
Alfiia I Aminova, Arch Gen Intern Med 2019, Volume 3
DOI: 10.4066/2591-7951-C2-025
Alfiia I Aminova is a Paediatric faculty from Seche-
nov First Moscow State Medical University, Russia.
She is the Head of the clinic Federal Research
Center for Medico-Prophylactic Technologies
for Health Risk Management during 2009-2013.
She is working as a Lecturer at two different Uni-
versities. Her highest qualification is in Paediat-
rics and Gastroenterology. Her area of scientific
interests is children’s gastroenterology, ecology,
sports medicine and rehabilitation. She has more
than 300 publications, including 127 in peer-re-
viewed journals and she is the author of seven
inventions, two monographs and more than 30
manuals for doctors.
Alfiia I Aminova
Sechenov First Moscow State Medical University, Russia
BIOGRAPHY