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Page 35
Cell and Gene Therapy 2018 & Clinical Microbiology Congress 2018
Biomedical Research
|
ISSN: 0976-1683
|
Volume 29
S e p t e m b e r 1 0 - 1 1 , 2 0 1 8 | D u b l i n , I r e l a n d
allied
academies
Joint Event on
CLINICAL AND MEDICAL MICROBIOLOGY
CELL AND GENE THERAPY
&
World Congress on
International Conference on
Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C3-008
COMBINED THERAPEUTIC MEDICAL DEVICE AND STEM CELLS FOR
REGENERATIVE NANOMEDICINE
N Benkirane-Jessel
Université de Strasbourg, France
I
n our group we explore a new generation of smart living implants combining not only active therapeutics but also stem cells,
as a novel strategy to regenerate stabilized cartilage and avoid prosthesis, by achieving regeneration of its subchondral bone
foundation, requirement which is failing today in the clinic. In our group, a unique nanotechnology strategy is used to entrap,
protect, and stabilize therapeutic agents into polymer coatings: nanoreservoirs, covering nanofibres of implantable nanofibrous
membranes for bone and cartilage regeneration. Upon contact with cells, therapeutic agents become available through enzymatic
degradation of the nano reservoirs. As cells grow, divide, and infiltrate deeper into the porous membrane, they trigger slow and
progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. The nano-reservoirs technology enables
to reduce the quantities of required therapeutic agent (compared to soaked membranes for instance) thereby reducing costs.
Clinical trial: phase 1, (FR, UK, SP, SW) will be submitted. Feasibility and safety assessment of a therapeutic implant based on an
active polymeric wound dressing and autologous mesenchymal stem cells derived from bone marrow for the treatment of femoral
cartilage isolated lesions.