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CANCER STEM CELLS AND
ONCOLOGY RESEARCH
11
th
International Conference on
Journal of Medical Oncology and Therapeutics
|
Volume 3
Guo-fu Hu et al., J Med Oncl Ther 2018, Volume 3
ANGIOGENIN AND PLEXIN-B2
INHIBITION SENSITIZES PROSTATE
CANCER STEM CELLS TO
CHEMOTHERAPY
Guo-fu Hu
1,2
, Shuping Li
1
, Kevin A Goncalves
1,2
and
Baiqing
Lyu
1
1
Tufts Medical Center, Washington, USA
2
Tufts University, Medford, USA
A
ngiogenin (ANG) and its receptor Plexin-B2 (PLXNB2) has recently
been shown todichotomously regulate the stemnessof hematopoietic
stem and progenitor cells (HSPC). While
ANG
and PLXNB2 preserve
quiescence of the primitive stem cells, they promote proliferation of more
differentiated progenitor cells. Here we show that ANG-PLXNB2 also
dichotomously regulates the properties of cancer stem cells (CSC) and
differentiated bulk cancer cells. Prostate CSCs were cloned from PC3,
LNCaP, and DU145 cells, and shown to have self-renewal, differentiation,
and tumor-initiating capacities. While ANG-PLXNB2 enhance proliferation
of differentiated prostate cancer cells, they restrict proliferation of
CSCs and promote quiescence through specific cleavage of 5S rRNA.
Monoclonal antibodies against both ANG and PLXNB2 were found to
mobilize CSC out of quiescence, sensitive them to chemotherapy, and
prevent disease relapse.
Guo-fu Hu, PhD, is currently a Professor of Med-
icine, Tufts University School of Medicine, and
an Investigator at Tufts Medical Center. He re-
ceived his PhD from Shanghai Institute ofBio-
chemistry, Chinese Academy of Sciences, and
did his postdoctoral training in Beret L. Vallee
lab located at the Center for Biochemical and
Biophysical Sciences and Medicine, Harvard
Medical School. He established his research
program first in the Department of Radiology,
Brigham and Women’s Hospital, and then in
the Department of Pathology, Harvard Medical
School, where he raised to the rank of Associate
Professor of Pathology. He moved to Tufts Med-
ical Center in 2010.
guo-fu.hu@tufts.eduBIOGRAPHY