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CANCER STEM CELLS AND
ONCOLOGY RESEARCH
11
th
International Conference on
Journal of Medical Oncology and Therapeutics
|
Volume 3
Xianming Mo, J Med Oncl Ther 2018, Volume 3
THE CONSTITUTION OF CANCER
TISSUES: THE PROPERTIES AND
IMPLICATION OF CANCER STEM
CELLS DERIVED FROM PATIENTS’
SAMPLES
Xianming Mo
Sichuan University, China
T
he growth of cancers depend on the formation of blood vessels that
provide the supply of nutrients and oxygen and the nervous system
acts as a crucial part of cancer microenvironment. The angiogenesis and
vasculogenesis are essential during cancer progression. Recently, several
studies have reported that glioblastoma stem cells are able to give rise to
tumor vascular endothelial cells (ECs) and vascular pericytes for tumor
vascularization. However, there is no evidence to show that the tumor
stem cells from other kinds of tumors including carcinoma produce
endothelial cells to constitute the functional blood vessels in cancer. In
addition, recent evidences have demonstrated that the stimulation of both
cancer growth and metastasis by members of nervous system such as
neurons. How the nervous system built in cancer tissues is unknown. We
transplanted the cancer stem cells that were isolated from the patients
with gastric and colorectal carcinoma into nude mice via subcutaneous
and intraperitoneal injections to produce human cancer xenografts. Then
the innervations, angiogenesis were examined and the origins of the
neural cells and endothelial cells were determined in cancer tissues. A
single cancer stem cell from the cancer tissues of human patients was
able to generate neurons including sympathetic and parasympathetic
cells to take part in the nervous system in cancer tissues. Knocking down
the neural generating capabilities of the human cancer stem cell inhibited
the growth of tumors. Next, we show that cancer stem cells of the human
colorectal carcinoma (CoCSCs) give rise to vascular endothelial cells and
compose the vasculatures in cancer tissues. NuMA+ EC incorporated
blood vessels were functional. Dependent on the biology of cancer stem
cell, we identified small molecules to drive the differentiation of the cancer
stem cell for restricted cancer grow. Our data demonstrate that neural
cells and endothelial cells originated from human cancer stem cells
constitute blood vessels and nerve system for the cancer progression
in the cancer tissues. The findings are able to guide the development of
therapeutic approaches to restrict cancer.
Xianming Mo is a professor of internal medi-
cine and acts as Director of Laboratory of Stem
Cell Biology, State Key Laboratory of Biothera-
py, West China Hospital, Sichuan University.
He obtained his medicine degree from North
Sichuan Medical College. Then he was trained
in pathology and accept Master of Medicine in
West China University of Medical Science. After
obtaining a PhD degree in Peking Union Medical
College, He moved to Humboldt-Universität zu
Berlin and then to Medical College of Georgia
as postdoctoral fellows. Then, he became junior
faculty in Medical College of Georgia and senior
scientist in Max Delbruck Center for Molecular
Medicine. In 2006, he returned back to West Chi-
na Hospital.
xmingmo@scu.edu.cnBIOGRAPHY