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Journal of Medical Oncology and Therapeutics | Volume: 3
July 23-25, 2018 | Moscow, Russia
12th World Cancer Congress
Morphological features and clinical significance of different types of tumor vessels in Gastric and
Breast Cancer
Marina Senchukova
Orenburg State Medical University, Russian Federation
Purpose: To study the features of morphology and clinical
significance of different types of tumor vessels in gastric (GC)
and breast cancer (BC).
Material and methods: Tumor samples of 73 patients with GC
and 59 patients with BC were stained withMayer’s hematoxylin
andeosinandimmunohistochemically,usingantibodiestoCD34.
Results: The following types of tumor vessels and structures
with endothelial lining were identified: normal capillaries, dilated
capillaries (DCs), atypical DCs (ADCs), “cavitary” structures type-
1 (CS type 1) – the structures with partial endothelial lining and
“cavitary” structures type-2 (CS type-2) – the distinctive cellular
structures in peritumoral stroma. The ADCs, CS type-1 and CS
type-2 most significantly correlated with the clinical features
of GC and BC. In GC the multiple CS type-1 and ADCs were
associated with T3-4 (p = 0.001) and N2 (p = 0.001) stages and
with a decrease of overall survival from 93.9% to 52.7% (p = 0,
0013) and relapse-free survival from87.7% to 32.4% (p = 0.0001);
in BC - with estrogen receptors negative status (p = 0.03), with
the presence of tumor emboli in vessels (p = 0.08) and with a
decreaseof relapse-free survival from85.7%to56.2% (p= 0.046).
As for the CS type-2, these structures were more often detected
in diffuse type of GC (p = 0.07). In BC the CS type-2 were more
often observed in positive Her2/new status (p = 0.008).
Conclusion: In GC and BC the tumor vessels are heterogeneous
in morphology and clinical significance.
Speaker Biography
Marina Senchukova has completed her PhD at the age of 36 years from Orenburg
State Medical Academy and Grand PhD in Medical sciences at the age of 53 years from
Orenburg State Medical University. She is the professor of the Oncology Department
of Orenburg State Medical University. She has coauthored over 100 publications
including Journal of Cancer, Springerplus, Current Angiogenesis, Morfologiia (Russia),
Voprosy Onkologii (Russia) and others. She holds six patent of Russian Federation.
The current main research interests include: mechanisms of tumor angiogenesis,
epithelial-mesenchymal transformation, role of inflammation in tumour progression.
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