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Journal of Medical Oncology and Therapeutics | Volume: 3

July 23-25, 2018 | Moscow, Russia

World Cancer Congress

Nonopioid painkillers as an alternative to a conventional therapy

Sergey Kozlov

Russian Academy of Sciences, Russia

ain is an unpleasant sensation with negative emotional

background that warns the body about dangerous pressure

and protects it from a damage. However, there is another kind

of pain, which instead of body protection brings unreasonable

anguish. The most undesirable kind of pain should be

considered cancer pain caused by the hyperactivation of the

nociceptive system. Such intense and chronic pain exhausts

patients both physiologically and psychologically as well as

influences on recovery processes. Properly selected painkillers

can not only alleviate the pain, but contribute to the therapy

in general. Two systems of nociception and antinociception

are closely interrelated in human to maintain a balance of pain

stimuli recognition. Opioids are actively used drug for pain relief

in cancer therapy. These molecules turn on the antinociceptive

system through the activation of mu and delta opioid receptors.

We suggest to put in the practice alternative painkillers that

can directly inhibit the nociceptive system and do not affect

on opioid receptors activation as well. First of all, this approach

allows to reduce the numerous side effects of prolonged

opioids administration during therapy. The long lasting

analgesic effect of novel drug seeds caused by their inhibitory

effect on the ion channels widely represented in the peripheral

neurons of mammalian nociceptive system and involved in pain

stimuli detection and further signal transduction. Two much

promising drug seeds undergo preclinical trials and already

have shown safety for animals and lack of additive effect.

Speaker Biography

Sergey Kozlov is the head of a laboratory of neuroreceptors and neuroregulators.

His research oriented on active molecules development and characterisation of

their biological function in cells. He has a lot of patents on compounds suitable for a

practical use in medicine.