3 / 16
Page 14
Notes:
allied
academies
Journal of Medical Oncology and Therapeutics | Volume: 3
July 23-25, 2018 | Moscow, Russia
12
th
World Cancer Congress
Relationship between body surface area and encephalization quotient in Chemotherapy of Brain
Cancers: The functions of four modified formulas
Saganuwan Alhaji Saganuwan
University of Agriculture Makurdi, Nigeria
T
reatment for ssBrain cancer is a difficult task, because of
complex nature of physico-chemical properties of brain,
central nervous systen (CNS) acting drugs and drug carriers.
Recently, Saganuwan derived a unique body surface area (BSA)
formula for calculation of doses of anticancer drugs for dog and
human, which correlates very well with their encephalization
quotient (EQ).Therefore von Bronin’s and Jerison’s formulas
were modified to BSA formulas. The four formulas used are for
Saganuwan (EQ=E/0.14 X BW
0.528-
; BSA=BW
0.528
X H
0.528
X O.14),
Jerison (EQ=E/0.12 X BW
0.67-
; BSA=BW
0.67
X H
0.67
X O.12), von
Bronin (EQ=E/0.18 X BW
0.66-
; BSA=BW
0.66
X H
0.66
X O.18) and the
resultant formula derived from the above formulas (EQ=BWX β
X H
β
X K/BSA), respectively . But brain mass is (E=kpβ),whereas
p (body weight), k (constant) and β (exponent) are integral
part of EQ formulas. The findings revealed that Saganuwan’s
formula yielded low effective therapeutic doses of anticancer
drugs for brain cancers in dogs and humans and high values of
EQs. However, Jerison’s and von Bronin’s formulas yielded high
BSA and low EQ values, respectively. Therefore high EQ denotes
low dose of anticancer for brain cancer. Hence EQ and BSA can
be used to determine safe therapeutic doses for brain cancers.
Speaker Biography
Saganuwan Alhaji Saganuwan is an Associate Professor of Pharmacology holds DVM, PGD,
PGDE, MSc and PhD in Pharmacology. He has been lecturing at University of Agriculture
Makurdi since 2005 with 70 publications in the journals of high repute. His areas of
research interest are pharmacology, toxicology, oncology and medicinal chemistry. He
was head of department for over 2 years. He is on editorial board of about 10 journals
and reviews for about 15 journals of high repute. He has presented conference papers
in the USA, UK, Australia, Japan, China, India, Italy, Spain, Cyprus among others.
e:
pharn_saga2006@yahoo.com