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J Med Oncl Ther 2017 | Volume 2 Issue 3
Breast Cancer November 01-02, 2017 | Toronto, Canada
7th World Congress on
Colorectal cancer (CR) is the second most common cause
of cancer death in Uganda. Although outcomes have
improved, it is clear that from a genomic standpoint CR is not
one disease, but a heterogeneous group of malignancies that
arise within one organ. Given that different subtypes have
different outcomes, the ability to subtype tumours in the
clinic would be highly favourable, enabling optimal treatment
for individual patients. In 2015, a consortium proposed
four consensus subtypes for CRC (MSI immune, canonical,
metabolic, and mesenchymal) based on six classifications
systems reported to have prognostic value. However,
genomic assessment of tumours is not readily translated
into routine pathology with a need for standardisation and
reproducibility of assessment. Immunohistochemistry is
widely used in routine pathology, and would present a more
readily translatable method for subtyping CRC tumours.
Therefore, the literature was reviewed to characterise the
genomic and phenotypic features associated with each
subtype, with the aim of enabling subtyping of CRC to be
taken forward into routine clinical practice.
e:
Colorectal cancer subtypes: Translation to routine clinical pathology
Kyomukama Prisca
Rubaga Division, Uganda