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allied
academies
J Med Oncl Ther 2017 | Volume 2 Issue 3
Breast Cancer
November 01-02, 2017 | Toronto, Canada
7
th
World Congress on
Background:
Data on health-related quality of life (HRQoL)
changes among Americans aged ≥65 following colorectal
cancer (CRC) diagnosis and treatment are limited. This study
compared HRQoL changes among CRC patients across stages
from before to after diagnosis with matched noncancer
controls.
Methods:
This population-based study used the Surveillance,
Epidemiology, and End Results Medicare Health Outcomes
Survey (MHOS) data set (2011-2015). Medicare Advantage
beneficiaries diagnosed with CRC between their baseline
and follow-up MHOS (n = 349) were matched to noncancer
controls (n = 1745) using propensity scores. Mixed-effects
analysis of covariance models estimated changes in HRQoL
(measured by the Medical Outcomes Study Short Form-36/
Veterans RAND 12-item Survey) and the ability to perform 6
activities of daily living (ADLs) between baseline and follow-
up. Logistic regression models estimated odds ratios for ADL
impairments and major depressive disorder (MDD) risk.
Results:
Mean time between CRC diagnosis and follow-up
MHOS was 12.3 ± 9.8 months. Compared with controls,
CRC patients had significantly lower scores in all physical
and mental health domains at follow-up. The greatest
decrements were observed in physical health and were
largely driven by declines in the 6 months postdiagnosis and
in stage III and IV patients. At follow-up, CRC patients had
greater overall ADL impairment and difficulty with dressing,
eating, and getting in/out of chairs. CRC patients, particularly
stage IV patients, had greater odds of being at risk for MDD
relative to controls.
Conclusions:
This study further underscores the adverse
effects of CRC on physical health and the need to support
older Ugandas’ basic self-care needs, with attention to later-
stage patients’ increased debility.
e:
jcrc@jcrc.co.ugImpact of colorectal cancer diagnosis and treatment on health-related quality of life among older
Ugandans: A population-based, case-control study
Yiga Godfrey Bukenya
Joint Clinical Research center, Uganda