4 / 11
Page 30
allied
academies
J Med Oncl Ther 2017 | Volume 2 Issue 3
Breast Cancer
November 01-02, 2017 | Toronto, Canada
7
th
World Congress on
B
reast cancer remains a serious world-wide problem. It
continues to be the leading form of cancer in women
both in North America and in developing countries. More
than 200,000 women are diagnosed with breast cancer each
year in the U.S. alone. The mainstays of treatment continue
to be surgery, radiation, chemo- and endocrine therapies,
although the anti-cancer potencies of several natural agents
have entered clinical trials, including herbal supplements,
vitamins, sponge and coral derivatives, and a range of
dietary products. Notably, many are used by women with a
recent diagnosis of breast cancer without their physician’s
knowledge. Although none has proven curative, dietary
agents are seen by many as safe, low-risk alternatives to the
more potent chemotherapeutic drugs currently used against
breast cancer. One example is genistein, a soy-derived
phytoestrogen which is known to have cytoprotective as
well as cytotoxic effects on breast cancer cells. It is estimated
that over one million women consume phytoestrogens
worldwide even though questions regarding their effects on
breast cancer risk, progression, and/or treatment responses
are largely unsettled. In our studies three different human
breast cancer cell sublines were established using long-term,
low-dose exposure protocols. This was accomplished by
passing a single parental cell line inmedia supplementedwith
genistein, estradiol, or tamoxifen as well as unsupplemented
media used for controls, followed by maintenance in
parallel for a period of two years. The resulting sublines
were characterized for changes in DNA- and ligand-binding;
target gene activation; estrogen receptor expression, cell
morphology, growth and survival; as well as ploidy; cell
cycle distribution, and responses to treatment with the anti-
cancer agent paclitaxel.
e:
janice.schwartz@hc.msu.eduThe Soy – Breast Cancer Question
Janice Schwartz
1,2
and
Brigette Gerard
2
1
Michigan State University College of Osteopathic Medicine, USA
2
Wayne State University School of Medicine, USA