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S e p t e m b e r 0 6 - 0 7 , 2 0 1 8 | B a n g k o k , T h a i l a n d
Biotechnology Congress 2018 & Emerging Materials 2018
Note:
Page 33
alliedacademies
EMERGING MATERIALS AND NANOTECHNOLOGY
BIOTECHNOLOGY
&
Annual Congress on
Global Congress on
Joint Event on
Biomedical Research | ISSN: 0976-1683 | Volume 29
Kampon Sriwatanakul, Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C4-009
POTENTIAL OF PROBIOTICS AS A
NEW BIOTHERAPEUTIC AGENT FOR
BOOSTERING THE IMMUNE SYSTEM
Probiotics or heath-beneficial bacteria have recently been introduced
as the new biotherapeutic agents for boostering immune system as
well as treatments of several chronic diseases. Probiotics have also been
demonstrated to exert positive effects on the composition of gut microflora
and overall health. This presentation provides an overview research and
development of probiotics, emphasizing non-dairy foods that contain probiotic
bacteria. Production of the Lactobacillus genus is found mostly in dairy
products with yogurts, kefir and cultured drinks. Our research group decided
to use the plant sources which are more beneficial and have much less side
effects than animal products. Cordyceps militaries, Houttynia cordata and
other immune-boosting herbs were carefully selected as the raw materials
for probiotic production. The finished product contained mixture of probiotics
including L Plantarium, L acidophilus, B subtilis and Saccharomyces cerevisiae.
It was well recognized that a healthy body is dependent on a strong immune
system. Probiotics help maintain intestinal microbial balance and gut mucosa
development. Our pilot studies indicated the potential applications of this
plant-based probiotic mixture in the treatments of chronic allergies, frequent
infections and autoimmune disorders. The immune status tests also showed
marked increases in NK cell, CD4, CD8 cell counts as well as restoring immune
balance. We believe that probiotics communicate with the host by proteomic
recognition receptors, such as nucleotide binding oligomerization domain,
which modulate key signalling pathways. Our future goal of research is to
explore probiotic mode of action focusing on how gut microbiome influence
the host immune system.
Biography
Kampon Sriwatanakul is an internationally recog-
nized pioneer of stem cell therapy, received MD
degree and PhD degree from Mahidol University
where he had an academic career for more than
35 years. He has also received training in Clinical
Pharmacology from University of Leicester, UK
and University of Rochester, USA. Apart from pub-
lishing more than 40 publications in international
journals, he has spearheaded several important re-
search and development activities related to stem
cell technology in Thailand, including setting up of
cord blood and tooth cell banking.
Kampon Sriwatanakul
Vitastem Co, Ltd, Thailand