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N o v e m b e r 2 1 - 2 2 , 2 0 1 8 | M a d r i d , S p a i n
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Analytical Chemistry 2018 Journal of Chemical Technology and Applications| Volume 2
ANALYTICAL CHEMISTRY
International Conference on
Nour Eddine ES-SAFI, J Chem Tech App 2018, Volume 2
APPLICATION OF MASS SPECTROMETRY
AND NMR ANALYTICAL TECHNIQUES
TO THE STRUCTURAL ELUCIDATION OF
PHENOLIC COMPOUNDS
Nour Eddine ES-SAFI
Mohammed V University in Rabat, Morocco
Polyphenols are natural products involved in plants defense. They are rec-
ognized as one of the largest and most widespread class of plant constit-
uents occurring throughout the plant kingdom and are also found in substan-
tial levels in commonly consumed fruits, vegetables and beverages. Phenolic
compounds form one of the main classes of secondary metabolites with a
large range of structures, and contribute to the organoleptic and nutritional
qualities of fruits and vegetables. Polyphenols have attracted considerable
interest because of their ubiquitous occurrence within the plant kingdom and
numerous important properties. They are receiving increasing attention as
natural antioxidants and potential health promoting agents and their eventu-
al health effects are attracting considerable interest in the international sci-
entific community. Many epidemiological studies suggested that long term
consumption of diets rich in plant polyphenols offer protection against de-
velopment of several chronic pathologies. Most of the experimental results
demonstrate that polyphenols have several biological activities. Phenolic
compounds are also highly unstable compounds which undergo numerous
enzymatic and chemical reactions during postharvest food storage and
processing thus adding to the complexity of plant polyphenol composition.
Among these compounds flavonoids (flavones, flavonols, anthocyanins, pro-
anthocyanidins, ..) constitute one of the most ubiquitous groups of all plant
phenolics. Owing to their importance in food organoleptic properties and in
human health, a better understanding of their structures, their reactivity and
chemical properties in addition to the mechanisms generating them appears
essential to predict and control food quality. Therefore, a number of efforts
have been made during the last decades to design versatile analytical tech-
niques to explore their structural characterization. The aim of this lecture is to
present an overview of our findings on polyphenols and their importance on
human health. Results concerning their isolation, their structural elucidation
through NMR and MS techniques, their hemisynthesis in addition to some of
their biological properties will be given.
Nour Eddine ES-SAFI completed his PhD in organic
chemistry in 1997 from Mohammed V University in Ra-
bat, Morocco. He undertook postdoctoral studies and
research at the French National Institute for Agricultural
Research. He is currently working at the Ecole Normale
Supérieure, Mohammed V University in Rabat as depu-
ty director and a full professor. His research focuses on
natural products, especially polyphenols, their structural
elucidation, their antioxidant activity and their role in food
technology and human health. He has published many
research papers and he is reviewer for various interna-
tional scientific journals. He is editorial board member
of various scientific journals and is editor in chief of the
Green and Sustainable Chemistry journal.
BIOGRAPHY