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J Parasit Dis Diagn Ther 2017 | Volume 2 Issue 4
International Conference on
Zoology, Microbiology & Medical Parasitology
October 30-November 01, 2017 | Chicago, USA
Results of molecular-genetic and epizootological monitoring of the Saryjaz autonomous area of Tien-Shan
mountains natural foci of the plague
Ziyat Abdel
Genesis Kazakhstan, Kyrgyzstan
Statement of the Problem:
After 30 years of the long stable
period, plague activity within the transboundary Sari-Dzhas
natural focus located in Kyrgyzstan and Kazakhstan, has
increased since 2012. The main objective is to survey plague
activity and role of natural hosts of plague, grey marmots
(
Marmota baibacina
) and plague vectors – fleas and other
ectoparasites in Sari-Dzhas.
Methodology & Theoretical Orientation:
The survey of
ecological, microbiological and epidemiological parameters
of plague activity in the Sari-Dzhas natural focus was
conducted each year from 2012 to 2016. Overall, 772
marmots, 418 small rodents, 1376 rodent ectoparasites were
tested for plague, as well 32 strains of
Yersinia pestis
were
characterized. Among them, 16 strains were isolated from
the Sari-Dzhas focus before 2012 and 16 strains after 2012.
The latter included strain obtained from human patient after
plague outbreak in 2013. For VNTR analysis, DNA fragments
of five reference strains of
Y. pestis
were used: CO92 (biovar
Orientalis
), KIM10 (biovar
Medievalis
), Pestoides F, Nepal516
(biovar
Antiqua
) and Y. pseudotuberculosis 2841. The strains
were provided by Department of Pathology of the University
of Texas Medical Branch.
Findings:
The density of marmots population in Sari-Dzhas
focus increased from 26.7 animals per 1
sq.kmin 2012 to
51.7 in 2016. Reproductive status of marmots was also higher
in 2016 comparing to 2012: The proportion of reproductively
active marmot females (pregnant or lactating) increased
from 33.3% to 46.6%. The load of marmots flea during this
period increased from 0,4 to 13,7. The strains of
Y. pestis
identified in the Sari-Dzhas natural focus belonged to
Antiqua and
Medievalis biovars
.
Conclusion & Significance:
The circulation of plague
pathogen within territory of the Sari-Dzhas natural focus
was continuous, but with evident fluctuation of activity. The
activity of plague depends on host-parasite system, including
multiple abiotic and anthropogenic factors.
Speaker Biography
Ziyat Abdel is the head of Biomedicine and Cell Biotechnology Laboratory of Scientific
Production Enterprise “Antigen” and Executive Director of Center for Medicine and
Prevention “Genesis Kazakhstan”, Almaty, Kazakhstan. After graduation the Karaganda
State Medical Institute, specializing in hygiene, sanitation and epidemiology, he has
completed Ph.D of Medical Sciences and is a doctor of highest category in social hygiene
and health care organization. In 2011-2016 years he was the head of plague laboratory
of Kazakh Scientific Center for Quarantine and Zoonotic Infections. He has 30 years-
long practical experience in epidemiology and microbiology of especially dangerous
infections, from them 21 are in anti-plague service. Abdel Ziyat has 4 author’s
certificates on innovative patents and deposited strains of especially dangerous
infections, 55 scientific publications in Kazakhstan and international publications. He
is a member of 2 international NGOs, was the head of many scientific and technical
programs and participant of international scientific projects.
e:
abdelziyat767@gmail.com