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academies
International Surgery and Ortho Conference
October 25-26, 2017 | Toronto, Canada
Case Rep Surg Invasive Proced 2017 | Volume 1 Issue 3
Failure to demonstrate the role of high risk human papilloma virus in epithelial ovarian cancer
Bibi Ghodsied Seyyedi Alavi, Nourieh Sharifi, Ali Sadeghian, Alireza Rezaei
and
Hossein Shidaee
Mashad University of Medical Sciences, Iran
Background & Aims:
Ovarian cancer is one of most common
causes of cancer related women’s mortalities. Human
papilloma virus is a known factor concerning cervical cancer
but its role in causing ovarian cancer is not yet verified. A
few studies also identified HPV DNA in ovarian carcinoma
tissues. However, some studies did not detect HPV DNA in
ovarian carcinoma tissues. In this article, we investigated
the potential role of high risk HPVs in the ovarian epithelial
carcinoma.
Methods:
Fifty archived epithelial ovarian cancer paraffin
blocks were collected. Then, 30 non-malignant ovarian blocks
were used as control. These samples were histopathologically
were confirmed by a pathologist and the proper blocks for
DNA extraction and PCR were sorted. PCR was conducted
deploying highly specific primers for high-risk types of HPV
(18 and 16) according to the instructions of Manufacturer
Company.
Results:
High-risk oncogenic sequences were identified in 4
(5%) of the 80 studied samples. Of the 4 HPV positive cases,
there was 1 case with normal tissue, 1 case of mucinous cyst
adenocarcinoma, and 2 cases of serous cyst adenocarcinoma.
Conclusion:
Surprisingly, our findings could not support any
association between high-risk oncogenic human papilloma
virus (18 and 16) and malignant ovarian epithelial cancer.
Therefore, that HPV is highly unlikely to play any causal role
in the pathogenesis of epithelial ovarian neoplasia.
Speaker Biography
Ghodsieh Alavi has obtained her Doctorate degree in Medical Sciences in Mashhad
University of Medical Sciences in 1979. With encouragements from her mother for
promoting women’s health, she continued her education in Gynecology and Obstetrics
specialty from 1980 to 1984 and from 1984 to 2011 she was a Faculty Member of
Ghaem Hospital, Mashhad, Iran. Since 1984, she has been a Manager in Alavi Medical
Clinic/Women’s Cancer Clinic and since 2001 to present, she is Manager of the
Gynecology Ward and Hospital Board Consultant in Bent Al-Hoda General Hospital,
Mashhad, Iran.
e:
Zahra.FattahiMassoom@uoit.ca