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S e p t e m b e r 0 3 - 0 4 , 2 0 1 8 | B a n g k o k , T h a i l a n d
Structural Biology 2018 & STD AIDS 2018
Note:
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allied
academies
STD-AIDS AND INFECTIOUS DISEASES
STRUCTURAL BIOLOGY AND PROTEOMICS
&
International Conference on
International Conference on
Joint Event on
Journal of Genetics and Molecular Biology
|
Volume 2
Gautam Sethi, J Genet Mol Biol 2018, Volume 2
TARGETING ONCOGENIC
TRANSCRIPTION FACTORS FOR CANCER
THERAPY
S
ignal transducers and activators of transcription (STATs) comprise an
important class of transcription factors that have been implicated in a
wide variety of essential cellular functions related to proliferation, survival,
and angiogenesis. Among various STAT members, STAT3 is frequently
overexpressed in tumor cells as well as tissue samples and regulates
the expression of numerous oncogenic genes controlling the growth and
metastasis of tumor cells. I will briefly discuss the importance of STAT3 as
a potential target for cancer therapy and provide novel insights into various
classes of existing pharmacological inhibitors of this transcription factor that
can be potentially developed as anti-cancer drugs.
Biography
Gautam Sethi has completed his postdoctoral
training at University of Texas, MD Anderson Can-
cer Center, and joined Department of Pharmacol-
ogy, Yong Loo Lin School of Medicine, National
University of Singapore in 2008 as an Assistant
Professor and was promoted to Associate Profes-
sor in 2015. The focus of his research over the past
few years has been to elucidate the mechanism of
activation of oncogenic transcription factors such
as NF-kB/STAT3 by carcinogens and inflammato-
ry agents and the identification of novel inhibitors
of these proteins for prevention and therapy for
cancer. The findings of his research work have so
far resulted in more than two hundred scientific
publications in high impact factor peer reviewed
journals (with h index=71) and several international
awards. He currently serves as an Academic Edi-
tor for PLOS, Editorial Board Member of
Scientific
Reports, Pharmacological Research, BMC Cancer,
Frontiers in Pharmacology, Frontiers in Oncology,
Journal of Natural Products in Cancer Prevention
and Therapy
, and ad-hoc reviewer for several other
prestigious international journals.
phcgs@nus.edu.sgGautam Sethi
National University of Singapore, Singapore