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Journal of Brain and Neurology | Volume 3
allied
academies
March 14-16, 2019 | London, UK
12
th
International Conference on
8
th
International Conference on
Vascular Dementia and Dementia
Neurological Disorders and Stroke
Joint Event
&
A
rapidly progressing aging society has raised attention to
white matter lesions in Alzheimer’s disease. Such an aging
societieshaveshownanincreasinglystrongrelationshipbetween
Alzheimer’s disease (AD) and chronic cerebral hypoperfusion
(HP). In the present study, we created a new mouse model
for AD with HP, and investigated its clinical and pathological
characteristics. Alzheimer’s disease transgenic mice (APP23)
were subjected to bilateral common carotid arteries stenosis
with ameroid constrictors for slowly progressive cerebral HP.
In contrast to simple APP23 mice, cerebral HP exacerbated
motor and cognitive dysfunctions with white matter lesions
and meningo-parenchymal amyloid-β (Aβ) burdens. Strong
cerebrovascular inflammation and severe amyloid angiopathy
with cerebrovascular remodeling were also observed in APP23
+ HP mouse brains. Compared with the wild type and simple
APP23 mice, APP23 + HP mice showed a progressive loss of
MAG and NF186 from6 to 12months, brokenmisdistribution of
MBP, and extended relocation of Nav1.6 and AnkG beyond the
primary nodal region in the corpus callosum. The present study
demonstrates that chronic cerebral HP enhanced cognitive/
motor dysfunctions with parenchymal/cerebrovascular Aβ
accumulation and cerebro- vascular remodeling, and that
cerebral HP strongly disrupted white matter integrity (WMI) at
intermodal, paranodal, and Ranvier’s nodal sites which may be
associated with cognitive decline.
Speaker Biography
Koji Abe is chairman of Neurology at Okayama University Medical School in Japan. He
graduated Tohoku University School of Medicine (M.D.) and then got PhD title fromTohoku
University under the direction of Prof. Kyuya Kogure. He published more than 600 papers
on cerebral blood flow and metabolism and neurodegenerative diseases. He is the past
president of the International Society of Cerebral Blood Flow and Metabolism (CBFM) and
organized World CBFMmeeting in Osaka in 2007 and Japan-Asia CBFMmeeting Okayama
city in 2014. He is currently serving Presidents of both Vas-Cog Japan and Vas-Cog Asia
societies.
e:
abekabek
@cc.okayama-u.ac.jpKoji Abe
Okayama University, Japan
Chronic Cerebral Hypoperfusion accelerates Alzheimer’s Disease pathology with
Cerebrovascular Remodeling in a novel mouse model