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allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Biomedical Research
|
Volume 29
Page 30
Note:
Joint Event on
Introduction:
Over the past 30 years there has been a significant
reduction in mortality following severe TBI together with improved
outcome. This has been largely due to the use of evidence-based
protocols emphasizing the correction of parameters implicated
in secondary brain injury. The main parameters are cerebral blood
flow, cerebral oxygenation and management of co-morbidities.
Neuroinflammation is a well-established secondary injury mechanism
following TBI.
Methodology:
Inspired by success in Parkinson’s and other
neurodegenerative diseases, stem cell based therapy is believed
to provide biobridges, can stabilize blood-brain barrier, reduce the
oxidative stress and provide immunomodulation and neuroprotection.
Hyperbaric oxygen may alleviate secondary insult in TBI through the
modulation of the inflammatory response. Animal studies showed that
hyperbaric oxygen improves neuroplasticity, reduce the inflammatory
markers and neuronal apoptosis following TBI.
Sources of stem cells:
Modulating endogenous stem cells or Cell
transplantation (using exogenous stem cells) from fetal/embryonic,
bone marrow stromal cells, umbilical cord cells or induced pluripotent
stemcells (iPSCs).There isplentyof literatureshowinggood responseof
stemcell therapy, mesenchymal stemcells in particular, on the outcome
in rat TBI models.The animal models indicate some vulnerability of the
stem cells to the hostile environment of neuroinflammation, which may
limit their potential.
Conclusion:
The results although very encouraging, are still in the
laboratory/preclinical phase and lots of technical, ethical and logistic
issues have to be solved before shifting to clinical trials. Hyperbaric
oxygenation can provide less hostile microenvironment helping with
repair and provide better use of stem cell induced growth factors.
Biography
Hazem Ahmed Mostafa is an internationally rec-
ognized neurosurgeon with over two decades of
clinical and research experience. He has devoted
his career to developing and providing rigorous,
comprehensive and compassionate care to
those with cancer, neurological degenerative dis-
eases andpediatric disorders. He’s affectionately
known as Dr Brain and Spine. He is a professor
in the Department of Neurosurgery at Ain Shams
University, Egypt since 2014. He is a Consultant
of Neurosurgery at his own private clinics Neuro-
Clinic Cairo and Hurghada - Red Sea, Egypt since
2001. Hazem has dedicated a significant part of
his career to developing innovative educational
research with over 33 published research papers
in the Egyptian Society journal. Hazem is an active
member of the Egyptian Society of Neurological
Surgeons since 1997. He is an international Fac-
ulty at AO Trauma Foundation. He is also an inter-
national fellow member of the Institute of Brain
Chemistry and Human Nutrition (IBCHNUK).
massappealpr@gmail.comSTEM CELLS AND HYPERBARIC
OXYGEN THERAPY FOR
TRAUMATIC BRAIN INJURY
MANAGEMENT
Hazem Ahmed Mostafa
Ain Shams University, Egypt
Hazem Ahmed Mostafa, Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-004