7 / 9
allied
academies
CARDIOLOGY AND CARDIOVASCULAR MEDICINE
STEM CELLS AND REGENERATIVE MEDICINE
&
International Conference on
International Conference on
J u n e 1 8 - 1 9 , 2 0 1 8 | O s a k a , J a p a n
Biomedical Research
|
Volume 29
Page 29
Note:
Joint Event on
I
n our group we explored a new generation of smart living implants
combining not only active therapeutics but also stem cells, as a
novel strategy to regenerate stabilized cartilage and avoid prosthesis,
by achieving regeneration of its sub-chondral bone foundation,
requirement which is failing today in the clinic. Aunique nanotechnology
strategy is used to entrap, protect, and stabilize therapeutic agents into
polymer coatings: nano-reservoirs, covering nano-fibres of implantable
nano-fibrous membranes for bone and cartilage regeneration. Upon
contact with cells, therapeutic agents become available through
enzymatic degradation of the nano-reservoirs. As cells grow, divide,
and infiltrate deeper into the porous membrane, they trigger slow and
progressive release of therapeutic agents that, in turn, stimulate further
cell proliferation. The nano-reservoirs technology enables to reduce
the quantities of required therapeutic agent (compared to soaked
membranes for instance) thereby reducing costs.
Biography
Nadia Benkirane is Research director and head of
the “Regenerative Nano¬medicine” laboratory, at
INSERM. She was leader of “Active Biomaterials
and Tissue Engineering” team INSERM 977. She
received her PhD. from University Louis Pasteur,
France. She joined the IN¬SERM U595 in 2002
as a post-doc, and re¬ceived the diploma to di-
rect the research (HDR) in 2004. Jessel got the
permanent position (CR1) in the INSERM 595
laboratory in 2004 and Research Director (DR2)
posi¬tion in the INSERM 977 and head of “active
Biomaterials and Tissue Engineering team.
nadia.jessel@inserm.frCOMBINED THERAPEUTIC
MEDICAL DEVICE AND STEM
CELLS FOR REGENERATIVE
NANOMEDICINE
Nadia Benkirane-Jessel
French National Institute of Health and Medical
Research, France
Nadia Benkirane-Jessel, Biomed Res 2018, Volume 29 | DOI: 10.4066/biomedicalresearch-C2-004