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Journal of Neurology and Neurorehabilitation Research | Volume 3
allied
academies
November 26-27, 2018 | Dubai, UAE
Spine and Spine Disorders
Addiction Research and Therapy
3rd International Conference on
International Conference on
Joint Event
&
T
he primary reinforcing actions of drugs of abuse including
nicotine and the conditioned motivational effects of
environmental stimuli (e.g., smoking) associated with previous
drug intake may be mediated by dissociable, yet connected,
neurobiologicalmechanisms.Weusedanimalmodelsofnicotine
self-administration and cue-induced relapse of nicotine-seeking
behavior to examine effects of pharmacological blockade of
specific neurotransmitter receptors on nicotine intake and
cue-triggered nicotine seeking. Male Sprague-Dawley rats
were trained to intravenously self-administer nicotine (0.03
mg/kg/infusion) on a fixed ratio 5 schedule of reinforcement.
To establish a nicotine conditioned cue, an auditory/visual
stimulus (5-s tone/20-s lever light on) was associated with each
nicotine infusions. After lever responding was extinguished
by withholding nicotine and its cue presentation, the cue-
induced reinstatement tests were performed. Prior to the self-
administrationandthereinstatementtestsessions,animalswere
subjected to receptor antagonist treatment to block activation
of specific neurotransmitter receptors. Antagonists of the α4β2
nicotinic acetylcholine receptors (nAChRs) but not theα7 nAChR
antagonists reduced nicotine self-administration. In contrast,
antagonists of the α7 nAChRs rather than the α4β2 nAChR
antagonists effectively reversed cue-induced reinstatement
of nicotine-seeking behavior. These results suggest distinct
involvement of the α4β2 and α7 subtypes of the nAChRs in
nicotine primary and conditioned reinforcement. In addition,
although bupropion suppressed nicotine self-administration,
its enhanced cue-triggered reinstatement of nicotine-seeking
behavior.Takentogether,thesefindingsmayhaveimplicationsfor
clinical effort to develop pharmacotherapies aimed at reducing
nicotine consumption in current smokers and preventing
environmental cue-triggered relapse in abstinent smokers.
Speaker Biography
Xiu Liu is a professor at the University of Mississippi Medical Center, USA. He has a
two-decade track record of studying drug addiction, particularly nicotine and alcohol
addictive behavior in animal models. His research has been funded by USA National
Institute of Health and Food and Drug Administration grants. He has published 60
research papers, 6 book chapters and more than 80 research abstracts. Dr. Liu has
served as a member of grant review panels for international and national research
funding agencies and an editorial boardmember of more than a dozen reputed journals.
e:
xliu@umc.eduXiu Liu
University of Mississippi Medical Centre, USA
Differential roles of α4β2 and α7 nAChRs in Nicotine Addiction process: Implications for
smoking cessation medication development