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Journal of Biomedical Research | Volume 29
October 22-23, 2018 | Frankfurt, Germany
International Conference on
Robo t i c s a n d A u t oma t i o n
B iomater ial s and Nanomater ial s
Joint Event
&
Localization of bone morphogenetic protein-2 (BMP-2) with
continuous and effective osteogenic stimulation is still a great
challengeinboneregeneration.Inourstudy,BMP-2wastethered
upon chondroitin sulfate (CS)-functionalized calcium phosphate
cement (CPC) scaffolds via specific noncovalent interactions (in
a biomimetic form). The fabricated scaffolds not only controlled
the release kinetics and presentation state of rhBMP-2, but also
effectively increased the expressions of bone morphogenetic
protein receptors (BMPRs) and enhanced the recognitions
of remained BMP-2 to BMPRs. In vivo studies demonstrated
that BMP-2-loaded CS-functionalized CPC exhibited sustained
release of the protein and induced high quality ectopic bone
formation. Thus, this work could provide new avenues in
mimicking bone extracellular matrix microenvironment and
localizinggrowthfactoractivity forenhancedboneregeneration.
Speaker Biography
Baolin Huang is a young principal investigator of School of Life Science, Guangzhou
University, China. In June 2011, he graduated from Donghue University, China as a
Bachelor of Engineering. In June 2017, he completed his PhD under the supervisor of
Prof. Changsheng Liu from East China University of Science and Technology, China. During
October2014toOctober2015,hestudiedatQueenslandUniversityofTechnology,Australia
as a Joint-Training PhD student. Since July 2017, he is a lecturer of Guangzhou University,
China. He published 8 papers in Q1 Journals (mostly Materials Science, Biomaterials). He
is the members of Chinese Society for Biomaterials, Queensland Chinese Association of
Scientists and Engineers, and Australian Nanotechnology Network.
e:
Baolin Huang
Guangzhou University, China
Biomimetic localization of bone morphogenetic protein-2 bioactivity by
chondroitin sulfate
Baolin Huang, Robotics & Biomaterials 2018, Volume 29
DOI: 10.4066/biomedicalresearch-C6-015