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Journal of Public Health and Nutrition | Volume 2
July 05-06, 2019 | Paris, France
International Conference and Exhibition on
17th World Congress on
Probiotics, Nutrition and Functional Foods
Pediatrics and Nutrition
Joint Event
&
Thehuman vaginalmicrobiotaplays an important role in the
maintenanceof awoman's health, aswell as of her partner
and new-borns. When this predominantly Lactobacillus
community is disrupted or decreased in abundance, Vaginitis
may occur. Of the millions of cases of vaginitis each each
year, most are caused by bacterial vaginosis (BV), followed
by Vulvovaginal candidiasis (VVC). BV is a dysbiosis of the
vaginal environment that due to frequent recurrences is one
of the most frequent causes of gynaecological examination,
BV can cause economic, social and psychological damage.
BV is associated with ascending infections and obstetrical
complications, such as chorioamnionitis and pretermdelivery,
aswell aswithurinary tract infections and sexually transmitted
infections. Vulvovaginal candidosis (VVC) is the second most
common cause of vaginitis, and it is diagnosed in up to 40% of
women with vaginal complaints in the primary care setting.
Despite therapeutic advances, candidiasis remains a common
fungal infection most frequently caused by C. albicans while
other species such as C. tropicalis, C. glabrata, C. parapsilosis
and C. krusei are increasingly isolated. Therapy with oral
or local recommended antibiotics is often associated with
failure and high rates of recurrences. (Antibiotics cannot
always penetrate the pathogenic biofilm) The dominance of
lactobacilli in healthy vaginal microbiota and its depletion in
BV and VVC has given rise to the concept of oral or vaginal use
of probiotic Lactobacillus strains for treatment and prevention
of vaginitis. Probiotics, defined as live microorganisms
that, when administered in adequate amounts, confer a
health benefit on the host, are considered a valid and novel
alternative for the prevention and treatment of female
urogenital tract infections. Probiotics are well known for their
ability to lower intravaginal pH, thus establishing a barrier
effect against many pathogens. Some strains are also able
to create additional and more focused antagonistic activities
mediated by specific molecules such as hydrogen peroxide
and bacteriocins. In any case, despite some undeniable
positive evidence, other intervention studies have at least
partially failed to highlight a statistically significant alleviation
of BV and VVC symptoms. This ismost likely attributable to the
lack of a specific inhibitory activity of the strains used towards
the bacteria commonly causing BV, such as G. vaginalis and
E. coli, and VVC such as C. albicans. Herein we present in
vitro and clinical data to assess the effectiveness of specific
probiotic strains in oral supplement, for the treatment of BV
and VVC, and the prevention of recurrences.
Speaker Biography
Franco Vicariotto, Medicine Doctor is a specialist in Obstetrics and
Gynecology and is now a senior consultant of San PIO X Hospital of
Milan. He graduated in Medicine and Surgery at University of Milan,
where he also achieved the specialization in Obstetrics and Gynecology.
He is currently specialist consultant at Humanitas-S.PIO X Hospital of
Milan and at Lower Genital Tract Disease Unit at the V. Buzzi Hospital
- University of Milan. He is currently in the Board of several scientific
societies. In the Board of SIM, the Italian Society of Menopause
Founder and in the Board of SIFIOG (Italian society of supplements
in Obstetrician and Gynecology). Founder and honorary president of
ISDSP (international society of dietary supplements and phytoterapy) In
the field of menopause he is a co-author of the guidelines for hormone
and non-hormonal therapy With his long experience as a specialist in
Gynecology, He is a clinical advisor on women’s health for several Italian
and International companies. He is also a clinical advisor for IQVIA
Health. Author of many publications and moderator-spokesman in
scientific meeting and conferences in Italy and international He speaks
English and German.
e:
Franco Vicariotto
University of Milan, Italy
Probiotics in the treatment of (Vulvovaginal Candidiasis) VVC and
(Bacterial Vaginosis) BV