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Page 52
November 13-14, 2017 Paris, France
5th International Conference on
PLASMA CHEMISTRY AND
PLASMA PROCESSING
Journal of Biotechnology and Phytochemistry
Volume 1, Issue 2 Plasma Chemistry 2017
Cold plasma treatment to support healing of
chronic wounds
K Masur1, Th von Woedtke1, H R Metelmann2, and K D Weltmann1
1Leibniz Institute for Plasma Science and Technology – INP Greifswald,
Germany
2Greifswald University, Germany
During the past decade the new interdisciplinary field of
research plasma medicine has been established. Applying
cold atmospheric pressure plasma may provide numerous
future applications in medicine, ranging from wound care
support, to blood coagulation, or medical device disinfection,
and even cancer treatment. Cold plasma consists of partially
ionized gas and contains several biological active components
including reactive oxygen and nitrogen species (ROS and
RNS), mild heat and UV-radiation. The challenge hereby
is to proof that plasma treatment can have lethal effects on
bacteria, whereas eukaryotic cells can be promoted to grow
and proliferate under the same conditions. Our aim was to
investigate the impact of cold plasma on the stimulation of
mammalian cells with respect to chronic wound healing.
Therefore, human cells from cell culture and from biopsies
were treated with the atmospheric pressure plasma jet kINPen
MED and other plasma sources to compare their effects on
treated cells. However, the underlying processes still need to
be identified to modulate the plasmas for future applications
– especially with respect to clinical application (including
patient diversity) and comparison of different plasma sources.
Our results indicate that for an optimal plasma treatment for
each plasma source the control of ambient conditions, as well
as a careful plasma treatment harmonized to the respective cell
line, or respectively the patients is of tremendous importance
for a successful approach of plasma therapy. Nevertheless,
future plasma applications in vivo demand for thorough
investigation on plasma-cell and plasma-liquid interactions
ensuring safety and reliability of devices in advance of its
clinical use. For future progression in the development of
medical devices, the standardization of plasma generating
processes as well as the biological tests is needed. This work
will provide some aspects on how to compare different plasma
treatment regimes, but also will give some hints what still
need to be investigated regarding patient treatments.
J Biot Phyt 2017