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O c t o b e r 1 9 - 2 0 , 2 0 1 8 | T o k y o , J a p a n
Pharma Congress 2018 & Molecular Medicine 2018
& Psychiatric Disorders 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X| Volume 8
International Conference on
PHARMACEUTICS AND NOVEL DRUG DELIVERY SYSTEMS
19th International Conference on
CELLULAR AND MOLECULAR MEDICINE
19th Annual Congress on
PSYCHIATRY AND PSYCHIATRIC DISORDERS
&
&
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Purwati, Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C3-008
THE ROLE OF ADIPOSE DERIVED
MESENCHYMAL STEM CELLS AS A
TREATMENT IN AUTOIMMUNE DISEASE
Purwati
Airlangga University, Indonesia
Autoimmune diseases (ADs) are the third most common disease in United
States affecting 5 to 8% of population. The major treatment of ADs is
immunosuppressive drugs, but these are not effective and associated with
substantial toxicities. Adipose tissue is one of the most potent and concen-
trated source of mesenchymal stem cells (MSCs) as an anti-inflammatory
and tissue protecting agent which is promote healing and minimal invasive. In
this study conducted in 20 patients with autoimmune diseases in various age
between 22 to 70 years old. Patients treated with autologous adipose-derived
MSCs transplantation through catheterization. The laboratory analysis result
of patients before and after MSCs application in 6 months were measured,
include hemoglobin (Hb), white blood cell (WBC), erythrocyte sedimentation
rate (ESR), protein and blood levels in urine, high sensitivity c-reactive protein
(hsCRP), C3 and C4 complement, anti-nuclear antibodies (ANA) and anti-dou-
ble stranded DNA (anti-dsDNA). MSCs can improve the performance of he-
moglobin as shown in Hb which statistically significant increased (p=0.002).
MSCs can reduce the inflammatory as shown in the number of leukocytes
(p=0.015) and ESR (p=0.031) which statistically significant decreased. MSCs
can repair the renal function as shown in no presences of protein and blood
in patient’s urine. MSCs are also able to augment the immune response as
shown in hsCRP which statistically significant decreased (p<0.001), while C3
and C4 complements statistically significant increased (p<0.001). ANA and
anti-dsDNA showed a negative result which means MSCs therapy may give a
good response to heal the ADs.
Purwati has done specialization in 2008 from Airlangga
University and has taken doctoral program in Airlangga
University 2010-2012. She is interested in stem cell field
from 2008, and she is the Secretary of Stem Cell Labo-
ratory of Airlangga University and Secretary of Surabaya
Regenerative Medicine Centre. She became Chairman of
Stem Cell Research and Development Centre Airlangga
University, Surabaya, Indonesia. She has almost 60 publi-
cations in journals, papers and seminar.
BIOGRAPHY