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O c t o b e r 1 9 - 2 0 , 2 0 1 8 | T o k y o , J a p a n
Pharma Congress 2018 & Molecular Medicine 2018
& Psychiatric Disorders 2018 Asian Journal of Biomedical and Pharmaceutical Sciences | ISSN: 2249-622X| Volume 8
International Conference on
PHARMACEUTICS AND NOVEL DRUG DELIVERY SYSTEMS
19th International Conference on
CELLULAR AND MOLECULAR MEDICINE
19th Annual Congress on
PSYCHIATRY AND PSYCHIATRIC DISORDERS
&
&
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
P Ndelo-di-Phanzu et al., Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C3-008
TOXICOLOGICAL ASPECTS OF
HELICOBACTER PYLORI INFECTION
ESTABLISHED IN DEMOCRATIC REPUBLIC
OF THE CONGO CONSECUTIVELY TO
MASSIVE POISONING SUSPICIONS ALL
OVER THE COUNTRY
P Ndelo-di-Phanzu, L Mputu Malolo, P Ndelo Matondo
Y Nuapia and S Mbendi Nsukini
University of Kinshasa, South Africa
Since a few decades, the population of the Democratic Republic of the Con-
go lives a sustainable poisoning fear all over the country. The reason is the
existence through the country of an odd health phenomenon characterized by
numerous extra-digestive pathologies unable to be diagnosed and looked af-
ter by the national health system. In 1990, Our Laboratory of Toxicology start-
ed a research work of the phenomenon in concern. In 2010, after 20 years
of trying, we established surprisingly an unexpected link with Helicobacter
pylori infection. Normally, Helicobacter pylori pathologies concern quite spe-
cifically the digestive tube. Recent literature however reports more and more
extra-digestive symptoms linked to Helicobacter pylori, but the passage of
Helicobacter pylori toxins to blood stream was not specified. Our research
work appears as a response to the international scientific community query.
Indeed, we established that Helicobacter pylori toxins released in stomach by
the reaction urea-urease linked to Helicobacter pylori, are in gaseous state.
After their release, they are normally excreted in stools but, in case of consti-
pation, instead of going down, they fly up along the esophagus, get the larynx
way and reach the lungs. From there, they enter then into blood circulating
system. The massive passage of Helicobacter pylori toxins in blood signs an
ammonia and carbon dioxide double intoxication. Our results have been pre-
sented in international conferences throughout the world and relevant publi-
cations have been made in international journals. Two case reports are also
exposed. In conclusion, Helicobacter pylori involves a strong toxic-infection
unknown in literature so far, instead of a simple infection, consecutively, ex-
tra-digestive pathologies reported in recent literature are easily understood
and the treatment changes to take in count the toxic component.
P Ndelo-di-Phanzu is a Congolese Toxicologist. After his
graduation as Pharmacist at the Faculty of Pharmacy of
the University of Kinshasa in 1975, he moved to Belgium
at the Faculty of Pharmacy of the Katholieke Universiteit
Leuven, where he performed a master’s degree in Phar-
maceutical Sciences followed by a doctorate degree in
Pharmaceutical Sciences, Branch Toxicology in 1984.
At the end of his post-graduate training, he went back
to the University of Kinshasa. He became Associate
Professor in 1986, Professor in 1998 and Ordinary Pro-
fessor in 2005. Considering the administrative level, he
was respectively Head of the Laboratory of Food and
Drug Control of the University of Kinshasa, Head of the
Department of Biopharmaceutical and Alimentary Sci-
ences, Head of the Laboratory of Toxicology, Vice-Dean
of the Faculty of Pharmacy of the University of Kinshasa,
Dean of the Faculty of Pharmacy, Rector of the University
of Kinshasa. In the field of ethics of Asian Journal of Bio-
medical and Pharmaceutical Sciences, he is President of
the Ethics Committee of Central Africa and Vice Presi-
dent of National Ethics Committee of DR Congo.
BIOGRAPHY