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Pediatric Congress 2019 Current Pediatric Research | ISSN: 0971-9032 | Volume 23
Page 25
July 25-26, 2019 | Amsterdam, Netherlands
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
International Conference on
PEDIATRICS AND NEONATOLOGY
METHICILLIN-RESISTANT STAPHYLOCOCCUS
AUREUS IN MELANESIAN CHILDRENWITH
HAEMATOGENOUS OSTEOMYELITIS FROM THE
CENTRAL HIGHLANDS OF PAPUA NEW GUINEA
Background: Methicillin-resistant Staphylococcus aureus (MRSA) has been an
important cause of bone infection since the 1940s. Current guidelines rec-
ommend targeted antibiotic use for osteomyelitis treatment informed by mi-
crobial sensitivity patterns. However, in settings without microbiology facili-
ties, empirical antibiotic use is common. Unrecognized antibiotic resistance
potentiates persistence of MRSA with osteomyelitis progression to chronic
forms with complications despite antibiotic treatment.
Method: A prospective observational study done to identify common etio-
logical agent(s) in bone infection in Melanesian children, observe for pres-
ence of antimicrobial resistance and determine effective antibiotic regimes
for treatment of bone paediatric osteomyelitis. 70 paediatric patients pre-
senting from the community with osteomyelitis were recruited, with bone
and non-bone specimens sampled, cultured and isolates tested for resistance
to common antibiotics.
Result: S. aureus was isolated in 67% (47/70) of collected specimens. Of the
47 isolates, therewas 91.5% resistance to penicillin, 85.1% resistance tometh-
icillin, 89.4% resistance to oxacillin, 93.6% resistance to ampicillin and 80.9%
resistance to ceftriaxone. S.aureus showed 91.5% sensitivity to gentamycin,
93.6% sensitivity to erythromycin, tetracycline and clindamycin and 95.7%
sensitivity to co-trimoxazole.
Conclusion: MRSA was the leading cause of haematogenous osteomyeli-
tis in Melanesian children. S.aureus was isolated mainly from infected long
bones of the lower limbs (79%) of children presenting from the communi-
ty, suggesting a predominantly community associated MRSA. S.aureus also
showed 80.9% resistance to ceftriaxone, indicating a potential multidrug
resistant MRSA strain. There was >91% sensitivity to chloramphenicol, tetra-
cyclin, co-trimoxazole, gentamycin and erythromycin which could be used to
effectively treat paediatric osteomyelitis in the region.
Izzard Aglua, Curr Pediatr Res 2019, Volume 23
Izzard Aglua holds an MBBS and MPH from
James Cook University, Australia. Currently he
coordinates clinical research on osteomyelitis,
stroke and MDR TB at the Kundiawa General
Hospital-Clinical Research Center in the Simbu
Province of Papua New Guinea. He also serves
as General Internal Medicine Registrar and Dive
Medical Officer for the region. His research work
includes identifying genotypes of MRSA isolates
from pediatric osteomyelitis and MDR TB isolates
from the hospital and assessing speed of re-
covery between right and left weaknesses after
stroke. He has recently published and presented
work on both stroke and osteomyelitis for which
he has received young researcher awards and
has recently joined the Editorial Board of the AS
Pediatrics and Current Pediatric Reviews .
Izzard Aglua
Sir Joseph Nombri Memorial-Kundiawa General Hospital,
Papua New Guinea
BIOGRAPHY