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Pediatric Congress 2019 Current Pediatric Research | ISSN: 0971-9032 | Volume 23
Page 29
July 25-26, 2019 | Amsterdam, Netherlands
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
International Conference on
PEDIATRICS AND NEONATOLOGY
PAEDIATRIC REFRACTORY EPILEPSY
AND VARIOUS KETOGENIC DIET – AN
ALTERNATIVE NON-PHARMACOLOGICAL
TREATMENT STRAGETY
Ketogenic diet is a high fat, moderate protein, very low carbohydrate, ratio spe-
cific therapeutic diet. The diet is used as a non-pharmacological, alternative
mode of treatment for the paediatric patients suffering from refractory epilepsy.
As per International League Against Epilepsy (ILAE) refractory or pharmaco-resis-
tant epilepsy is defined as failure of adequate trials of two tolerated, appropriately
chosen and used antiepileptic drug schedules (whether as monotherapies or in
combination) to achieve sustained seizure freedom. For children with glucose
transporter type 1 deficiency or pyruvate dehydrogenase complex deficiency,
ketogenic diet is the treatment of first choice. The principle of the diet is to uti-
lize fatty acid derived ketone bodies as the primary source of energy by replac-
ing glucose. In clinical practice there are several forms of ketogenic diet based
on ratio and composition. The efficacy of ketogenic diets has been established
by numerous randomized controlled trials. The classical ketogenic diet consists
of dietary saturated fat and is based on a ratio of 3:1 or 4:1 (fat:[carbohydrate +
protein]). In Polyunsaturated fatty acid ketogenic diet (PUFAKD) polyunsaturated
fats like omega-3 and omega-6 are used to produce ketone bodies. In a random-
ized control trial byYehuda et al, it has been shown that provision of PUFAKDwith
a ratio of 2.8:1 (omega 3:omega 6) has been proven most beneficial in reducing
seizure frequency among children with refractory epilepsy. Medium-chain tri-
glyceride (MCT) based ketogenic diet uses MCTs like coconut oil as major source
of fat in daily diet. MCT based ketogenic diet is less restrictive and provides similar
benefits as classical ketogenic diet. All mode of ketogenic diets are safe and easy
to administer in any outpatient setting. The diet has some reported side effects
which can be managed by close monitoring, supplementation and regular follow
up.The compliance for ketogenic diet is lowbut inclusion of various options could
change the monotony and increase compliance rate. The administration of keto-
genic diet requires qualified dietitian, neurologist, and psychologist on board for
error free experience with maximum outcome.
Subhasree Ray, Curr Pediatr Res 2019, Volume 23
Subhasree Ray is the ‘Corporate Dietitian’ of Re-
liance Industries Limited, heading the corporate
nutrition department of the organization across
India. She is a PhD scholar of Ketogenic Diet with
8 years of experience in Nutrition science and
Medical Nutrition Therapy. She has worked with
Govt. of India in eradication of child malnutrition
for 2 years. She is a public speaker of Nutrition,
health, wellness and lifestyle management. She
has authored 17 scientific research articles in
various national and international journals. She
has also presented her research work in 18 con-
ferences, workshops and seminars. She has re-
ceived ‘Young Researcher Award’for her research
in probiotic and HIV. She is an advisor for many
organizations and companies dealing with food
and nutrition as their major component. She is
the reviewer and editorial board member of two
reputed international journals and one national
journal. She is the lifetime member of Indian Di-
etetic Association, Nutrition Society of India and
Probiotic Association of India.
Subhasree Ray
Reliance Industries Limited, India
BIOGRAPHY