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Journal of Pathology and Disease Biology | Volume 2

September 06-07, 2018 | Edinburgh, Scotland

Pathology and Surgical Pathology

International Conference on

Extranodal NK/T-cell lymphoma, nasal type (angiocentric T-cell lymphoma) not associated with EBV

infection: A case report

Cocco P, Boschetto R, Gasparin P P, Farruggio A

and

Ferri E

Aulss 6 Veneto Region, Italy

xtranodal NK/T-cell lymphoma, nasal type (ENKL) is a rare

lymphoid neoplasm, which in the past has been grouped

with a variety of granulomatous diseases. It is characterized

clinically by aggressive, unrelenting destruction of the

midline structures of the palate and nasal fossa and has an

ominous prognosis. Histological diagnosis can be difficult

because of extensive tissue necrosis and multiple biopsies

are often required.

This is the case report of a 76-year-old male patient who

presentedwith nasal obstruction and foul smelling, ulcerative

lesion over the palate of 3 months duration, which had been

treated with antibiotics and anti-inflammatories without

success. Histopathological examination of the lesion was

done and showed a cellular picture, which was pleomorphic

with many large or immunoblast-like cells and relatively few

small lymphocytes. A striking feature was the angiocentric

distribution of the tumor cells and angiodestruction, which

mimed vasculitis. It was confirmed by immunohistochemical

analysis that the patient had an ENKL, nasal type. an

aggressive, locally destructive, midfacial, necrotizing lesions.

with death occurring due to relapse or systemic spread

in 50% of the cases. The nonspecific clinical symptoms

constitute a major stumbling block in the early diagnosis and

management of these lymphomas.

Speaker Biography

Cocco P graduated in Medicine and Surgery in 1987, specialized in Anatomical

Pathology in 1992 and in Hygiene and Preventive Medicine in 2018 at the

University of Padua (Italy). She completed a PHD in Risk Management In Health

in 2018 at the LUISS (Rome). Since 19 April 1993 he has been working at the

Pathological Anatomy and Citodiagnostics Unit of the AULSS 6 Padua (Veneto

Region): as Medical Director permanent employment relationship. She has over 30

publications that have been cited over 352 times, and her publication H-index is 10