31 / 39
Page 89
allied
academies
February 28-March 01, 2019 | Paris, France
Palliative Care, Obstetrics and Gynecology
Stroke and Clinical Trials
International Conference on
Joint Event on
International Conference on
&
Journal of Research and Reports in Gynecology and Obstetrics | Volume: 3
Reproductive function in female kidney transplant recipients
Anastasia Kudrytskaya
Belarusian State Medical University, Belarus
A
ccording to population registries prevalence of chronic
kidney disease (CKD) in the world is about 10%. Global
trends show growth of CKD due to chronic tubulointerstitial
nephritis, secondary nephropathies. Kidney transplantation
(KT) is a “gold standard’ in CKD treatment. Is was performed
362 times in 2017 in Belarus. The aim of the study was to
evaluate menstrual function and hormonal changes in
female kidney transplant recipients. The study included 55
women aged 18-44 who had undergone KT within last 5
years. They had adequate graft function confirmed by serum
creatinine, urea, cystatine C, glomerular filtration rate. They
were administered immunosuppressive drugs (Ciclosporin,
Tacrolimus, Azathioprin, Mucophenolate mofetil) in
different combinations. Patient’s history was collected by
questionnaire, hormone testing was conducted by ELISA.
Control group consisted of healthy regularly menstruating
women matched by age. 68% of women after KT have
regular menstruations with confirmed ovulation, 22%
show oligomenorrhea, 10% are amenorrheic. Menstrual
function restored within one year after KT. LH and FSH (on
5th and 25th days) showed no differences in both groups.
Oligomenorrhea was accompanied by significant decrease
in progesterone level to 5.48 pmol/L, statistically significant
(p<0.01) increase in estradiol level (up to 2.5 nmol/L) in
the follicular phase. Elevated prolactin level to 948 mME/L
(р<0.01) and significant decrease of testosterone level to
0.1 pg/mL (р<0.01) were found in 33% of KT recipients.
Antimullerian hormone was significantly (p<0.01) lower
(1.30-2.45 ng/mL) in regularly menstruating women after
KT than in oligo- or amenorrhea. Vitamin D concentrations
were comparable in two groups.
e:
anastasiasavchenko89@gmail.comRes Rep Gynaecol Obstet, Volume 3
DOI: 10.4066/2591-7366-C1-003