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September 23-24, 2019 | Prague, Czech Republic
2nd International Conference on
Palliative Care
Clinical Trials and Pharmacovigilance
Joint Event
&
Results of the application of an antiretroviral protocol to pregnant women with human
immunodeficiency virus in a service of North Eastern Brazil: A step towards improving
in palliative care
Otávio Soares de Pinho Neto
USP University Hospital, Brazil
Background: This study sought to analyze ART protocols
used in a cohort of HIV-positive pregnant women and
exposed newborns followed at a university hospital in
Northeast Brazil.
Methods: Retrospective cohort study of 153 pregnancies.
Descriptive statistics were used to characterize the
sociodemographic profile of mother- child pairs, prenatal
care, use of ART, and delivery, and an analysis of
antiretrovirals used and associated maternal and neonatal
outcomes was conducted. The t-test was used to evaluate
potential associations between categorical variables.
Results: The overall mother-to-child transmission rate
was 3.9%. More than 50% had been diagnosed before
pregnancy, 41%were on ART, and 70% had an undetectable
viral load at 34 weeks pregnancy. The mean CD4 count
was 440 cells/mL at baseline and 516 cells/mL after
ART. Overall, 92% of women were on ART with protease
inhibitors and 98% received intrapartum intravenous AZT.
Prematurity, presence of neonatal morbidity, and failure
to administer intrapartum AZT were associated with
84 increased risk of vertical transmission. There was a
low incidence of side effects associated with ART during
pregnancy; the most common was anemia, both maternal
(58.4 %) and neonatal (21.6%).
Conclusion: In this sample, mother-to-child transmission
was mainly associated with prematurity, neonatal morbidity,
and failure to administer intrapartum intravenous AZT. These
results may support interventions toward improving health
quality in palliative care methodologies.
Speaker Biography
Otávio Soares de Pinho Neto has Graduated in Medicine from the Federal
University of Paraíba (1985), Specialization in STD by the Brazilian Society of
STD (2000), Master in Human Development from the Federal University of
Paraíba(2006)andDoctorateinTocogynecologyfromtheStateUniversityof
Campinas(UNICAMP-2014).He isamemberof IberoamericanObservatory
of Health and Citizenship and member of the Editorial Committee of the
Iberoamerican Journal of Health and Citizenship since 2013. He was an
Invited Professor at Rey Juan Carlos University - Madrid and University of
Porto-Portugal(2015).MedicalDirectorAssistanceattheLauroWanderley
UniversityHospital/UFPBandeventualreplacementoftheSuperintendent
Director (2010-2013), Bayeux Municipality Doctor 1998-1999, Lucena
Municipality Doctor 2008-2014, Santa Maria Maternity Doctor 1997-2013.
e:
Journal of Primary Care and General Practice | Volume 2
J Prim Care Gen Pract, Volume:2