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Journal of Medical Oncology & Therapeutics | Volume 4

March 18-19, 2019 | London, UK

Oncology & Cancer Therapy

International Conference on

The role of c-Met endosomal signalling in cancer

Stephanie Kermorgant

Queen Mary University, London

he receptor tyrosine kinase c-Met is overexpressed in 20-

80% of cancers with the level of expression correlating

with metastasis and poor prognosis. We have shown that

upon activation, c-Met rapidly internalizes. However c-Met

continues to signal inside the cells on endosomes. Moreover

c-Met endocytosis is an important aspect of its oncogenic

properties. Thus we reported that c-Met mutants found

in cancer patients are oncogenic not only because they are

highly activated but also because they signal on endosomes.

We have shown that c-Met signalling from a late endosome

triggers breast cancer cellmigration.Wediscovered that beta1-

integrin and c-Met co-traffic through a novel “Autophagy

Related Endomembrane (ARE)”. From there, the integrin plays

the non-adhesive role of a scaffold to sustain c-Met signalling.

This leads to cell survival in anoikis and metastasis. Thus we

hypothesise that c-Met intracellular localisation and signalling

play major roles in cancer progression. A better understanding

of the molecular biology of intracellular c-Met may lead to

improved cancer treatment as well as improved biomarker

to select the patients who would respond to c-Met targeted

therapy.

Speaker Biography

Stephanie Kermorgant completed her PhD with Thérèse Lehy at the French National

InstituteofHealthandMedicine(INSERM)andParisVIIUniversity,France, in1999.Between

2000 and 2005, She performed postdoctoral studies with Professor Peter J Parker at the

Cancer Research UK London Research Institute. She joined the Centre for Tumour Biology

at the Barts Cancer Institute in May 2005, as a Lecturer. Thanks to a “Medical Research

Council New Investigator Award” and funding from the “Barts and the London Charitable

Foundation”, she set up her research group “Spatial Signalling”, which is investigating the

role of growth factor receptor signalling and trafficking in tumour metastasis.