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J Med Oncl Ther 2017 | Volume 2 Issue 4
allied
academies
Oncology and Biomarkers Summit
November 27-28, 2017 | Atlanta, USA
Annual Congress on
O
nly two percent of the human genome was shown to code
for proteins and the rest of the 80–90 percent was shown
to transcribe into non-coding RNAs. Micro RNAs (miRNAs) and
long noncoding RNAs (lnc RNAs) fall into this category of non-
coding RNAs. Recently, it was shown that noncoding RNA codes
for peptides that regulate the expression of active mature
miRNAs in plant cells. Here, we demonstrate the presence
of an ORF in non-coding RNAs which codes for peptides or
small proteins that show novel biological properties in human
cells. We show noncoding RNAs-encoded peptides/ proteins
(miPEPs) have homology to breast cancer tumor suppressor and
to proteins that promote longevity and health span. They also
inhibit the migration of cancer cells by regulating epithelial to
mesenchymal transition of these cells. These miPEPs have the
potential to serve as diagnostic markers for metastasis and can
also be used as therapeutic agents to many cancers. We have
also discussed how these novel peptides/proteins encoded by
noncoding RNAs are evolved in nature and their potential role
in cancer and other human diseases. Thus, these novel tumor
suppressors will revolutionize the future biology, diagnosis and
therapy.
Speaker Biography
E Shyam P Reddy is a Professor and Director, Cancer Biology Program, Department of
OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for excellence, Grady
Memorial Hospital, Atlanta, Ga. He carried out his PhD work at the Center for Cellular
and Molecular Biology, Hyderabad, India and at Max Planck Institute for Biophysical
Chemistry, Gottingen, West Germany. His PhD work was published as two papers (back
to back) in the prestigious Nature journal for which he was awarded National Young
Scientist award by the Prime Minister of India. He obtained postdoctoral training in
Molecular Biology at Yale University, CT (Dr Weissman, PNAS member).
e:
ereddy@msm.eduE Shyam P Reddy
Morehouse School of Medicine, USA
Decoding of non-coding DNA and non-coding RNA: Noncoding RNA-encoded
novel peptides/proteins regulate migration of cancer cells