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J Med Oncl Ther 2017 | Volume 2 Issue 4
allied
academies
Oncology and Biomarkers Summit
November 27-28, 2017 | Atlanta, USA
Annual Congress on
T
he level of hypoxia-inducible factor 1a (HIF-1a) plays
an important role not only in the development of in
hepatocellular carcinoma (HCC), but also in its metastasis,
recurrence and resistance to anti-tumor chemotherapy. ZBP-
89 is a transcription factor that binds to gene promoter GC-
rich sequence to activate or suppress the transcription of
genes that are associated with cell growth and cell death.
However, the relationship between HIF-1a and ZBP-89 is
unknown in HCC. In this study, we examined the levels of
HIF-1a and ZBP-89 in HCC cells and HCC tissue samples. We
found that the expression of HIF-1a was significantly in all
HCC tumor samples, compared with non-tumor liver tissues.
The levels of ZBP-89 was slightly increased in the well-
differential HCC tumor samples but obviously decreased in
moderately or poorly differential tumor samples, compared
with non-tumor liver tissue samples. Overall, the expression
of ZBP-89 was inversely correlated with the stage of the
tumor differentiation and the level of HIF-1a in HCC samples,
indicating that the higher HIF-1a, the lower ZBP-89. In
conclusion, there is a negative relationship between the
level of HIF-1a and the expression of ZBP-89 in HCC. The data
suggest that the low level of ZBP-89 may contribute to the
upregulation of HIF-1a. Considering the fact that ZBP-89 can
induce apoptosis in HCC cells, whether upregulation of ZBP-
89 will negatively impact the expression of HIF-1a remains an
interesting question.
Speaker Biography
George G Chen is a Professor in the Department of Surgery, Director of Surgical
Research Laboratories and Faculty of Medicine of Chinese University of Hong Kong,
China. He has extensive experience in cancer research, particularly in the area of liver
and lung cancers. He has authored or co-authored more than 200 papers and has
written a number of books or book chapters.
e:
gchen@cuhk.edu.hkGeorge G Chen
The Chinese University of Hong Kong, China
ZBP-89 and hypoxia-inducible factor 1a in hepatocellular carcinoma