3 / 7
allied
academies
Page 17
Insights Nutr Metab 2017
Volume 1 Issue 3
September 11-12, 2017 Edinburgh, Scotland
15
th
World Congress on
Advances in Nutrition, Food Science & Technology
Nutrition World 2017
Suppression of intestinally mediated diseases
by consumption of polyphenol rich sorghum
brans
P
olyphenols may protect against intestinally mediated
diseases such as obesity, type 2 diabetes, chronic
inflammation and cancer by influencing the colonic
bacteria and their metabolites. We demonstrated
diet induced modifications to the microbiota and
their metabolites in rodent models of disease and
overweight humans. When sorghum brans containing
3-deoxyanthocyanins, condensed tannins or their
combination were included in a purified diet, they almost
completely prevented microbial shifts that occurred
in rats given the polyphenol free diet. Microbiota
changes with the purified diet were suggestive of a pro-
inflammatory state. In animals challenged with dextran
sodium sulphate to initiate colitis, sorghum bran diets
mitigated intestinal inflammatory tone. This response
may result from the retention of Bacteroidetes and
inhibition of an increase in Firmicutes in rats consuming
the control diet. The condensed tannins increased
Akkermansia, a microbe considered protective against
metabolic diseases including diabetes. In addition to
affecting the microbiota, inclusion of condensed tannins
also causes a shift from rapidly digestible starch to slowly
digestible and resistant starch in the diet, which likely
contributed to a reduction in blood glucose levels that
occurred after a meal. Similar changes in the microbiota
and importantly, microbe derived plasma metabolites
occurred in humans consuming a cereal containing
condensed tannins. Finally, rats fed these sorghum
brans had fewer early colon cancer lesions, and this
was associated with changes in the expression of pro-
inflammatory mediators and regulators of apoptosis
induction. Overall, our data suggest the potential
for polyphenol rich brans derived from sorghum to
suppress multiple intestinally mediated chronic disease
states that negatively affects millions of people around
the world.
Biography
Nancy D Turner is a Research Professor in the Nutrition & Food Science
Department. Her research is focused on characterizing the mechanisms
whereby dietary chemoprotective compounds mitigate colon carcinogenesis and
inflammatory bowel disease, with special attention given to the interaction between
colon microbiota and the colonocytes. She has published 69 peer-reviewed
papers, 6 book chapters, and co-edited a book entitled “Potential Health Benefits
of Citrus”. She is the Director of PhD Training Program in Space Life Sciences
and Co-Director of a Postdoctoral Training Program in Nutrition, Biostatistics
and Bioinformatics. She serves on the editorial boards of Advances in Nutrition,
Molecules, and Experimental Biology and Medicine.
n-turner@tamu.eduNancy D Turner
Texas A&M University, USA
Nancy D Turner, Insights Nutr Metab 2017