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December 05-06, 2019 | Dubai, UAE
29
th
International Conference on
14
th
International Conference on
Nursing Education and Research
Cancer and Cancer Therapy
Joint Event
&
Journal of Intensive and Critical Care Nursing | Volume 2
Impact of human cytomegalovirus infection on survival of patients with Ovarian
Cancer
MinYin
and
Ai-PingChen
Qingdao University, China
H
uman cytomegalovirus (HCMV) has been detected in
various types of tumors. We studied the prevalence of
HCMV in ovarian cancer and its relation to clinical outcomes.
Paraffin-embedded tissues obtained prospectively from
60 patients with ovarian cancer, 30 patients with benign
ovarian cystadenoma and 10 patients with normal ovarian
tissue were analyzed for expression of HCMV immediate-
early protein (IE) and HCMV tegument protein (pp65)
by immunohistochemistry. Extensive HCMV-IE protein
expressionwas detected in 73%of ovarian cancers and 23%of
benign tumors; pp65 was detected in 65% ofovarian cancers
and 13% of benign tumors. A higher grade of HCMV infection
was associated with higher stage of disease. Extensive HCMV-
pp65 expression was associated with shorter median overall
survival than focal expression (37 versus 45 months, P=0.04).
At study closure, 55% of ovarian cancer patients with focal
pp65 expression were alive versus 28% of patients with
extensive pp65 expression (P=0.03). Thus, HCMV proteins
are detected at different levels in ovarian tumors and benign
cystadenomas. Ovarian cancer patients with focal HCMV-
pp65 expression in their tumors lived longer, highlighting
a need for in-depth studies of the oncomodulatory role of
HCMV in ovarian cancer.
e
:
1239096840@qq.comJ Intensive Crit Care Nurs | Volume 2