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April 11-12, 2019 | Barcelona, Spain
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Neuroscience Congress 2019
Journal of Neurology and Neurorehabilitation Research | Volume 4
NEUROSCIENCE AND
NEUROLOGICAL DISORDERS
2
nd
International Conference on
THE ROLE OF TEMPORAL LOBE ATROPHY IN PRE- SENILE DEMENTIA
Samia Othman Massaad
and
Mohammed Ahamed Abuelnour
Gadarif University, Sudan
Background and objective:
Dementia is a collection of signs and symptoms such as memory impairment,
difficulties of communication and planning, changes in mood and behaviour, and the gradual loss of control of
physical functions due to damage of the brain. It is of greater prevalence in older subjects, but many cases can
begin in an early age, affecting people in a productive phase of their lives. The aim of this study to investigate
the association of the temporal lobe atrophy in causing early onset dementia in Sudanese patients
Material & Methods:
Magnetic resonance imaging (MRI) method was used to detect atrophy of temporal
structures in thirty two patients diagnosed with dementia and Image-Pro Plus 6.0 to measures the volume.
Age of patients range between 52 to 65 years, and compared with 32 healthy control subjects of the same age.
Results:
A total of thirty tow files of subjects diagnosed with presenile dementia were examined, 21(65.6%) of
them were males and 11(34.4%) were females. the mean age of study subject was 60.15 year. A positive family
history was reported in tow patients (6.3%).
The imaging confirmed the expected temporal lobe atrophy in pre- senile dementia relative to controls, In 12
patients (38%), MRI show bilateral atrophy of the hippocampi. The volume of the hippocampus on the right
side of the patients was range between 9.39 – 10.23 cc while on the left side of the patients the volume range
8.94 - 9 cc compare to the controls that recorded 13.55-15.36cc and 12- 15.20 cc on the right and left side
respectively . Eight patients (25 %) had atrophy on medial temporal lobe include amygdala, insula, and orbitof-
rontal cortex and two (6 %) patients being parieto temporal atrophy. In addition to that, MRI showing atrophy
in the anterior part of left temporal lobe in the seven patients (22%).The volume of the left temporal lobe of
the patients was 26.7- 28 compare to the controls that range 39.83- 40cc. Other three (9.3%) showed bifrontal
and the temporal lobes atrophy the volume of the frontotemporal lobes were 47.81-47.90cc and 46.65-47cc
on the right and left side of the patients respectively compare to the control that measures 98.92 - 97.8cc on
the right and left side respectively.
Conclusions:
We conducted that hippocampal; amygdala, temporal pole, fusiform and infero lateral temporal
gyri atrophy are seen in patients with pre- senile dementia. These findings have a role for diagnosis and under-
standing of the pre- senile dementia.
J Neurol Neurorehabil Res 2019, Volume 4