neuroscience-congress-2019-accepted-abstracts

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April 11-12, 2019 | Barcelona, Spain

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

Neuroscience Congress 2019

Journal of Neurology and Neurorehabilitation Research | Volume 4

NEUROSCIENCE AND

NEUROLOGICAL DISORDERS

International Conference on

ASSOCIATION OF OXYTOCIN RECEPTOR (OXTR) GENE POLYMORPHISMS WITH

AUTISM SPECTRUM DISORDER (ASD): A CASE-CONTROL STUDYWITH CLINICAL

PROFILING

LoloWal Marzan

University of Chittagong, Bangladesh

utism spectrum disorder (ASD) is a group of sex biased neurodevelopmental disorders characterized by

core deficits in social behavior, communication and behavioral flexibility. Several lines of evidence in-

dicate that oxytocin signaling through its receptor (OXTR), is essential in a wide range of social behaviors.

Variable clinical profile of ASD with unique presentation of symptoms was found in our study. 92.23% of the

ASD patients (n=103), than the control groups (n=30) were found to have significant (p<0.0001) social inter-

action difficulties. Along with that common developmental concerns significantly associated with language

impairments (p<0.001), behavioral abnormalities like hypo or hyperactivity (p<0.003), repetitive behavior, re-

sistance to change (p<0.001), self-hurting activities (p<0.0001). Co-morbidities as depression (p<0.01), dyslexia

(p<0.0001), intellectual disability (p<0.001), sleep disturbance (p<0.001) are found to be significantly associ-

ated with ASD, which is co-related with anxiety and behavioral problems. Early recognition of symptoms and

the risk factors would help in appropriate therapeutic intervention resulting in favorable outcome. In attempts

to determine whether genetic variations in the oxytocin signaling system contribute to ASD susceptibility, we

have investigated the role of OXTR variants in ASD development in our Bengali of Bangladesh (BEB) population

of Chittagong region by analyzing four OXTR variants (rs53576, rs2254298, rs2228485, rs237911) through PCR-

RFLP method based on case-control study (37 cases, 15 controls). A significant (p<0.05) frequency for OXTR

rs53576 AA risk allele was found to be associated with ASD compare to controls which is consistent with the

previous study in Chinese but Caucasian and Japanese population. No significant association has been found

for OXTR variants (rs2254298, rs2228485, rs237911) in this study. These findings suggested to further investi-

gate in a larger sample size on OXTR rs53576 polymorphism towards ASD in overall BEB population as well as

ethnic group to open new avenue for clinical marker development for ASD diagnosis and treatment.

J Neurol Neurorehabil Res 2019, Volume 4