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Notes:

J Neurol Neurorehabil Res 2017 | Volume 2 Issue 3

allied

academies

International Conference on

NEUROLOGY AND NEUROSCIENCE

MENTAL HEALTH AND PRIMARY CARE

October 16-18, 2017 | Toronto, Canada

Takehiko Fujino

Kyushu University, Japan

Efficacy and blood plasmalogen changes by oral administration of plasmalogen in

patients with Alzheimer’s disease

educed levels of plasmalogens (Pls), a special class of

glycerophospholipids, have been reported in the brains and

the blood of patients with Alzheimer’s disease (AD). Therefore,

we have assessed the efficacy and safety of scallop-derived Pls

inpatientswithAD. The resultswere as follows: Themulticenter,

randomized, double-blind, placebo-controlled trial in patients

with mild AD and mild cognitive impairment; Of 328 patients

enrolled, 276 patients completed the trial. They orally received

either 1mg/day of Pls or placebo. Inmild AD patients, Wechsler

Memory Scale- Revised significantly improved among females

and those aged below 77 years in the treatment group. Non-

controlled trial in patients with moderate to severe AD; 53%

of 57 patients with moderate AD and 28% of 18 patients with

severe AD showed a significant improvement of Mini Mental

State Examination after the oral administration of 1 mg Pls daily

for threemonths. All patientswithmild to severeADshowed the

reduced levels of erythrocyte membrane and plasma Pls. Oral

administration of purified Pls derived from scallop increased

the levels of Pls in the peripheral blood. The improvement of

cognitive functions correlated with the increase of erythrocyte

membrane Pls. These findings suggest that oral administration

of scallop-derived purified Pls improve cognitive functions of

AD patients.

Speaker Biography

Takehiko Fujino is an Emeritus Professor of Kyushu University. He has graduated from

Medical School of Kyushu University, Japan, in 1964. He is strongly interested in the

Integrated Medicine, especially in the correlation between brain and other organs

although his specialty was initially Cardiology of Internal Medicine. He has advocated a

new concept “Brain Fatigue”, fromwhich many kinds of diseases might be induced, and

developed “BOOCS: Brain-Oriented Oneself-Care System”, a new method for removal

of “Brain Fatigue” in 1994. It has been known that many kinds of disorders such as

metabolic syndrome, depression and dementia were improved and then the death rate

of those patients decreased by “BOOCS” method. As one of those researches, he has

studied the correlation between plasmalogen and “Brain Fatigue”.