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N o v e m b e r 2 1 - 2 2 , 2 0 1 8 | M a d r i d , S p a i n
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Nephrology 2018 Journal of Clinical Nephrology and Therapeutics| Volume 2
NEPHROLOGY AND UROLOGY
International Conference on
Lu Xiuli et al., J Clin Nephrol Ther 2018, Volume 2
NETWORK IDENTIFYING PATHOGENIC
BIOLOGICAL EVENTS IN KIDNEY STONE
Lu Xiuli, Gao Bing, Yang Baoyu, Mao Jing and Zhang Weiwen
Liaoning University, China
Alarge number of promising genes/proteins have been found to be relat-
ed to the kidney stone formation. Identifying highly pathogenic biological
events in these candidates will advance our understanding of kidney stone
formation. We performed protein-protein interaction (PPI) networks analysis
by integrating datasets from four genome-wide association studies (GWAS),
a microarray study and a urine proteomics study. Highly connected genes/
proteins were calculated to construct corresponding direct network, respec-
tively. Permutation tests were performed to evaluate the networks reliability.
Backbone networks were extracted to acquire essential genes/proteins for
functional enrichment analysis. Overlaps were performed to identify accu-
mulations of abnormal genes, biological processes (BPs) and pathways. We
found that the abnormal accumulation were overlapped at three genes, in two
pathways and in five BPs. Abnormal changes accumulated in these genes,
pathways and BPs may increase risk of stone formation. Our findings provide
valuable information for screening potential biomarkers and further clarifying
kidney stone formation mechanism.
Lu Xiuli has completed her PhD at the age of 31 years
from Nagoya University, Japan. She is the professor of
Liaoning University, China.
BIOGRAPHY