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Mater Sci Nanotechnol 2017 | Volume 1 Issue 2
allied
academies
Nanomaterials and Nanochemistry
November 29-30, 2017 | Atlanta, USA
International Conference on
T
enoxicam (TX) is NSAID indicated to treat rheumatoid
arthritis but possess poor solubility, GI irritation and first
pass effect. Hence in the present work it was initially made
as nanoparticles to facilitate absorption and at later stage
nanoparticles loaded transdermal patches were developed
using promising nanoparticles of tenoxicam. Nanoparticles
were prepared with chitosan by ionic-gelation technique Trail
formulations such as F1 to F5 were prepared by using 0.25%
w/v sodium TPP and different concentrations of chitosan
(0.5%,1%, 1.5%,2% and 2.5%,w/v). These formulations were
evaluated for percent drug content, and % drug release
and mean particle size by zeta sizer. They were evaluated
by percentage drug content, in-vitro release, particle size,
zeta potential, DSC and FTIR analysis. Percentage drug
content values were in acceptable range of 99.1 -99.8%. All
formulations were produced in nanosizes and the sizes are
101.10nm, 108.7nm, 178.30nm, 314.3nm, and 923.2nm for
F1, to F5 in sequence. DSC and FTIR analysis indicated there is
no interaction between the drug and polymers. Among them
F4 having mean particle size 178.30nm and zeta potencial
of 35.5 mV45 was considered as pomising formulation.
Transdermal patches of TX were prepared by solvent casting
method using different ratios of polymers HPMC, E.C, and
PVP. Chloroform: methanol (1:1) was used as solvent. Dibutyl
phthalate and propylene glycol were added as plasticizer and
permeation enhancer respectively. Three formulations were
obtained with optimum properties in terms of percentage
drug content (98.56%-99.88%), thickness (1.7mm±0.03 to
1.3mm±0.021 surface pH (6.5 to 6.9), folding endurance
(191 to 200). Ex- vivo permeation studies of a patch (TT6)
containing HPMC K400M 880 mg EC, 270 mg and PVP 260
mg exhibited optimum drug release of 99.51% in 60 min.
e:
jeevanajyothi@yahoo.comDevelopment of nanoparticles loaded transdermal patches of tenoxicam
B Jeevana Jyothi
Sri Padmavati Mahila Visvavidyalayam, India