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Mater Sci Nanotechnol 2017 | Volume 1 Issue 2
allied
academies
Nanomaterials and Nanochemistry
November 29-30, 2017 | Atlanta, USA
International Conference on
V
ery recent advances in the nanochemistry and
nanomaterials research has provided a new set of
research tools, materials, structures and systems, for
biological and medical research and applications. Thus,
there has been extensive research and developments on
nanomaterials for healthcare applications viz diagnostics,
devices, therapeutics etc. Through the present talk, synthesis
and functionalization of nanomaterials for healthcare
application will be discussed. Looking at the scope of the
topic, the presentation will be limited to only metal oxide
nanomaterials, typically Fe
3
O
4
and ZnO nanoparticles,
for cancer and diabetes therapeutics. The first part will
be on Fe
3
O
4
nanoparticle for cancer therapeutics. Fe
3
O
4
nanoparticles have been explored for a very long time as a
promising drug delivery, MRI and cancer hyperthermia agent
in medical diagnostics and therapeutics segment. On the
other hand, curcumin, a natural organic material, due to its
inflammatory suppressing, antioxidant and tumor-resistant
and other such properties, is also known as ‘goldmine in
medicine’. But the limited bio-solubility of curcumin has
restricted its widespread application. In this context, we
have worked on exploring possible applications of the
synthesized Fe
3
O
4
-curcumin conjugates using citrate linker
(Fe-CA-CU), at an in-vitro level. The conjugation chemistry,
the loading percentage of curcumin in the system, and the
magnetic properties will be discussed. This will be followed
by the in-vitro studies, indicating its potential applications
in cancer therapeutics via 1) magnetic hyperthermia- site
specific tumor suppression and 2) exploring the therapeutic
uses (anti-oxidant and anti-inflammatory) of curcumin. The
development of promising solutions in diabetes therapeutics
has been another challenge in healthcare domain. The ever-
increasing number of patients and the side-effects, rather
adverse effects of the conventional systems-which include
enzyme inhibitor, have invited many scientists to develop
promising contender with minimal side-effects. As is well
known, Zinc has strong role in insulin synthesis, storage and
secretion and thus its deficiency can be related to diabetes.
In this context, natural extract of Red Sandalwood (RSW)
as a potent anti-diabetic agent, in conjugation with ZnO
nanoparticles was explored. ZnO nanoparticles have been
synthesized via soft chemistry routes and duly characterized.
The conjugation chemistry, extract loading percentage was
also studied. The anti-diabetic activity was assessed with
the help of like α-amylase and α-glucosidase inhibition assay
with murine pancreatic and small intestinal extracts. The
results will be discussed in the presentation. Besides, the
use of ZnO nanoparticle modified optical fiber sensors will
be discussed at the end.
e:
kitture.rohini@gmail.comMetal oxide nanomaterials for healthcare applications
Rohini Kitture
Defence Institute of Advanced Technology, India